| UniProt/SwissProt ID: | RALA_HUMAN |
| Description: | v-ral simian leukemia viral oncogene homolog A (ras related) [Source:HGNC Symbol;Acc:9839] |
| Location: | chr7 p14.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y82 | AIRDNyFRSGE | Ras | PhosphoSitePlus |
| S183 | RKMEDsKEKNG | PhosphoSitePlus; HPRD | |
| S22 | VIMVGsGGVGK | Ras | PhosphoSitePlus |
| Y75 | AGQEDyAAIRD | Ras | PhosphoSitePlus |
| Y153 | QWNVNyVETSA | Ras | PhosphoSitePlus |
| Y43 | EFVEDyEPTKA | Ras | PhosphoSitePlus |
| Y51 | TKADSyRKKVV | Ras | PhosphoSitePlus |
| S194 | KKKRKsLAKRI | PhosphoSitePlus | |
| S11 | PKGQNsLALHK | HPRD | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S183 | RARKMEDsKEKNGKK | PPP2R1B | HPRD |
| S194 | NGKKKRKsLAKRIRE | PPP2R1B | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000005257 | L14F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000005257 | G59W | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000005257 | R176* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000005257 | Breast Cancer | Cancer vs. Cancer (Non-TNBC vs. TNBC) | cell line | Up | 20596302 | |
| Hyperphosphorylation site |
| RALA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| 2AAB_HUMAN | RALA_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05200 | Pathways in cancer |
| hsa05212 | Pancreatic cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030496 | midbody | IEA | cellular_component |
| GO:0032154 | cleavage furrow | IDA | cellular_component |
| GO:0006913 | nucleocytoplasmic transport | IEA | biological_process |
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0031532 | actin cytoskeleton reorganization | IDA | biological_process |
| GO:0006886 | intracellular protein transport | IEA | biological_process |
| GO:0006887 | exocytosis | IEA | biological_process |
| GO:0006935 | chemotaxis | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0030139 | endocytic vesicle | IDA | cellular_component |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0000910 | cytokinesis | IDA | biological_process |
| GO:0017157 | regulation of exocytosis | IEA | biological_process |
| GO:0009986 | cell surface | IDA | cellular_component |
| GO:0051665 | membrane raft localization | IEA | biological_process |
| GO:0051491 | positive regulation of filopodium assembly | IDA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0031755 | Edg-2 lysophosphatidic acid receptor binding | IDA | molecular_function |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |