Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PVRL2_HUMAN
Description:poliovirus receptor-related 2 (herpesvirus entry mediator B) [Source:HGNC Symbol;Acc:9707]
Location:chr19 q13.32
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y454QEMPRyHELPTPhosphoSitePlus
T410SYKPPtPKAKLPhosphoSitePlus; HPRD
S519DALSYsSPSDSPhosphoSitePlus
S520ALSYSsPSDSYPhosphoSitePlus; HPRD
T459YHELPtLEERSPhosphoSitePlus
Y518YDALSySSPSDPhosphoSitePlus
S433GASEHsPLKTPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S185VALCIsKEGRPigPhosphoSitePlus
S405LEGPPsYKPPTPhosphoSitePlus; HPRD
S517IYDALsYSSPSPhosphoSitePlus
Y439PLKTPyFDAGAPhosphoSitePlus
S10AALLPsRSPPTPhosphoSitePlus
T172EAQKVtFSQDPPhosphoSitePlus
Y505EEEEEyLDKINPhosphoSitePlus
Y513KINPIyDALSYPhosphoSitePlus
S228FTLVPsGRADGigPhosphoSitePlus
Y537MSRAMyV____PhosphoSitePlus
S445FDAGAsCTEQEPhosphoSitePlus
T447AGASCtEQEMPPhosphoSitePlus
T390QRKEQtLQGAEPhosphoSitePlus

Dephosphorylation site
PVRL2_HUMAN do not have dephosphorylation site.

Mutation site
PVRL2_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000252483Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
PVRL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PVRL2_HUMANCD226_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04520Adherens junction
hsa04514Cell adhesion molecules (CAMs)
hsa05168Herpes simplex infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042271susceptibility to natural killer cell mediated cytIMPbiological_process
GO:0046814virion attachment, binding of host cell surface coIDAbiological_process
GO:0019064viral entry into host cell via membrane fusion witIDAbiological_process
GO:0002891positive regulation of immunoglobulin mediated immIMPbiological_process
GO:0015026coreceptor activityTASmolecular_function
GO:0002860positive regulation of natural killer cell mediateIMPbiological_process
GO:0007286spermatid developmentISSbiological_process
GO:0050839cell adhesion molecule bindingIPImolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0016021integral to membraneIDAcellular_component
GO:0001675acrosome assemblyIEAbiological_process
GO:0032990cell part morphogenesisIEAbiological_process
GO:0005915zonula adherensIEAcellular_component
GO:0050839cell adhesion molecule bindingIEAmolecular_function
GO:0045954positive regulation of natural killer cell mediateIMPbiological_process
GO:0007010cytoskeleton organizationIEAbiological_process
GO:0007286spermatid developmentIEAbiological_process
GO:0030382sperm mitochondrion organizationIEAbiological_process
GO:0009566fertilizationIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0034329cell junction assemblyTASbiological_process
GO:0045216cell-cell junction organizationTASbiological_process
GO:0033005positive regulation of mast cell activationIMPbiological_process
GO:0043064flagellum organizationIEAbiological_process
GO:0007289spermatid nucleus differentiationIEAbiological_process
GO:0051856adhesion to symbiontIDAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0051654establishment of mitochondrion localizationIEAbiological_process
GO:0050776regulation of immune responseTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007156homophilic cell adhesionIEAbiological_process
GO:0007156homophilic cell adhesionIDAbiological_process
GO:0005911cell-cell junctionIDAcellular_component
GO:0005915zonula adherensISScellular_component
GO:0034332adherens junction organizationTASbiological_process
GO:0060370susceptibility to T cell mediated cytotoxicityIDAbiological_process
GO:0005911cell-cell junctionIEAcellular_component


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