| UniProt/SwissProt ID: | PUM1_HUMAN |
| Description: | pumilio homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:14957] |
| Location: | chr1 p35.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y1154 | ATLRKyTYGKH | PhosphoSitePlus | |
| Y717 | GSSDLyKRTSS | PhosphoSitePlus | |
| T112 | KHRWPtGDNIH | PhosphoSitePlus | |
| S98 | LGGGGsGGGGY | PhosphoSitePlus; HPRD | |
| Y784 | NGSGRyISAAP | PhosphoSitePlus | |
| S228 | EYVLSsSPGDS | PhosphoSitePlus; HPRD; phosphoELM | |
| T711 | RRDSLtGSSDL | PhosphoSitePlus; HPRD; phosphoELM | |
| S197 | RRPGQsFHVNS | PhosphoSitePlus; HPRD | |
| Y795 | GAEAKyRSASS | PhosphoSitePlus | |
| S106 | GGYNNsKHRWP | PhosphoSitePlus; HPRD | |
| S229 | YVLSSsPGDSC | PhosphoSitePlus; HPRD; phosphoELM | |
| T60 | ALAAGtHSSPV | HPRD | |
| T810 | FSPSStLFSSS | PhosphoSitePlus | |
| S209 | VNSVLsPRSES | PhosphoSitePlus; HPRD; phosphoELM | |
| T514 | SQRPLtPNQNQ | PhosphoSitePlus | |
| S814 | STLFSsSRLRY | PhosphoSitePlus | |
| S806 | ASSLFsPSSTL | PhosphoSitePlus; HPRD; phosphoELM | |
| S202 | SFHVNsEVNSV | HPRD | |
| S809 | LFSPSsTLFSS | PhosphoSitePlus | |
| S75 | GVAGRsQDDAM | PhosphoSitePlus; HPRD; phosphoELM | |
| Y1168 | KLEKYyMKNGV | PhosphoSitePlus | |
| S797 | EAKYRsASSAS | PhosphoSitePlus | |
| T39 | MPVVLtSGTGS | HPRD | |
| S124 | EHQVRsMDELN | PhosphoSitePlus; HPRD | |
| T1150 | RPHIAtLRKYT | PhosphoSitePlus | |
| Y83 | DAMVDyFFQRQ | PhosphoSitePlus | |
| Y1123 | DQYANyVVQKM | PUF | PhosphoSitePlus |
| Y103 | SGGGGyNNSKH | HPRD | |
| S713 | DSLTGsSDLYK | PhosphoSitePlus | |
| S17 | VLWQDsFSPHL | HPRD; phosphoELM | |
| S709 | GSRRDsLTGSS | PhosphoSitePlus; HPRD; phosphoELM | |
| S206 | NSEVNsVLSPR | PhosphoSitePlus | |
| S714 | SLTGSsDLYKR | PhosphoSitePlus; HPRD | |
| S808 | SLFSPsSTLFS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y1113 | PHSALyTMMKD | PUF | PhosphoSitePlus |
| S19 | WQDSFsPHLKH | PhosphoSitePlus; HPRD; phosphoELM | |
| Y1120 | MMKDQyANYVV | PUF | PhosphoSitePlus |
| Dephosphorylation site |
| PUM1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000401777 | N307S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000257075 | G231D | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000257075 | N307S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000257075 | N1080S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000257075 | A688T | COSMIC | Pancreatic Cancer | ENSP00000257075 | D244N | COSMIC | Skin Cancer | 21984974 | ENSP00000257075 | S657G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000257075 | E848K | COSMIC | Central Nervous System Neoplasms | 21817013 | ENSP00000257075 | K256R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PUM1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PUM1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK6_HUMAN | PUM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | PUM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PUM1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006417 | regulation of translation | IEA | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0016044 | cellular membrane organization | TAS | biological_process |
| GO:0006892 | post-Golgi vesicle-mediated transport | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |