| UniProt/SwissProt ID: | PTSS1_HUMAN |
| Description: | phosphatidylserine synthase 1 [Source:HGNC Symbol;Acc:9587] |
| Location: | chr8 q22.1 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y416 | HREKTySECED | PhosphoSitePlus; HPRD | |
| S454 | NNESHsSRRRN | PhosphoSitePlus; HPRD; SysPTM | |
| S455 | NESHSsRRRNR | PhosphoSitePlus; HPRD; phosphoELM | |
| T415 | GHREKtYSECE | PhosphoSitePlus; HPRD | |
| S3 | ___MAsCVGSR | PhosphoSitePlus | |
| S11 | GSRTLsKDDVN | PhosphoSitePlus; HPRD | |
| S417 | REKTYsECEDG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y424 | CEDGTySPEIS | PhosphoSitePlus; phosphoELM | |
| S442 | KGSEDsPPKHA | PhosphoSitePlus; HPRD; SysPTM | |
| S7 | ASCVGsRTLSK | PhosphoSitePlus | |
| S462 | RRNRHsKSKVT | PhosphoSitePlus | |
| Y17 | KDDVNyKMHFR | PhosphoSitePlus | |
| T436 | HHRKGtKGSED | PhosphoSitePlus | |
| T423 | ECEDGtYSPEI | PhosphoSitePlus; HPRD | |
| S425 | EDGTYsPEISW | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| PTSS1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000430548 | H411Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000430548 | *474G | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PTSS1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTSS1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PTSS1_HUMAN | SCRB1_HUMAN | ligand -> receptor | HPMR |
| PTSS1_HUMAN | JMJD6_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa01100 | Metabolic pathways |
| hsa00564 | Glycerophospholipid metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0016020 | membrane | ISS | cellular_component |
| GO:0006644 | phospholipid metabolic process | TAS | biological_process |
| GO:0046474 | glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0016740 | transferase activity | IEA | molecular_function |
| GO:0005789 | endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0006659 | phosphatidylserine biosynthetic process | IEA | biological_process |