| UniProt/SwissProt ID: | PTH2R_HUMAN |
| Description: | parathyroid hormone 2 receptor [Source:HGNC Symbol;Acc:9609] |
| Location: | chr2 q34 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S18 | WLMLGsCLLAR | PhosphoSitePlus | |
| T354 | AVGHDtRKQYR | 7tm_2 | PhosphoSitePlus |
| T546 | GCQGEtEDVL_ | PhosphoSitePlus | |
| T546 | GCQGEtED | HPRD | |
| S445 | TPPCGsRRCGS | PhosphoSitePlus | |
| Dephosphorylation site |
| PTH2R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000272847 | E527Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000272847 | E527Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000272847 | D132H | COSMIC | Breast Cancer | 20668451 | ENSP00000272847 | R446H | COSMIC | Skin Cancer | 21984974 | ENSP00000272847 | D124N | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000272847 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 21 hour) | cell line | Down | 0.32 | 15169874 |
| Hyperphosphorylation site |
| PTH2R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TIP39_HUMAN | PTH2R_HUMAN | ligand -> receptor | HPMR |
| PTHY_HUMAN | PTH2R_HUMAN | ligand -> receptor | HPMR |
| PTH2R_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| PTH2R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0004991 | parathyroid hormone receptor activity | TAS | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |
| GO:0004888 | transmembrane signaling receptor activity | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |