Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRLR_HUMAN
Description:prolactin receptor [Source:HGNC Symbol;Acc:9446]
Location:chr5 p13.2
Node attribute:receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S195EFKILsLHPGQfn3PhosphoSitePlus
S349DPDTDsGRGSCPhosphoSitePlus; phosphoELM
T415GSKCStWPLPQPhosphoSitePlus; HPRD; phosphoELM
Y611LGGLDyLDPACPhosphoSitePlus; HPRD; phosphoELM
S361SPSLLsEKCEEPhosphoSitePlus
Y509AKPLDyVEIHKPhosphoSitePlus
Y202HPGQKyLVQVRfn3PhosphoSitePlus
S358SCDSPsLLSEKPhosphoSitePlus

Dephosphorylation site
PRLR_HUMAN do not have dephosphorylation site.

Mutation site
PRLR_HUMAN do not have mutation site.

Differential expressed protein
PRLR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PRLR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PRL_HUMANPRLR_HUMANligand -> receptorHPMR
PRL_HUMANPRLR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042110T cell activationNASbiological_process
GO:0038161prolactin signaling pathwayNASbiological_process
GO:0017046peptide hormone bindingIPImolecular_function
GO:0006694steroid biosynthetic processNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0004896cytokine receptor activityIEAmolecular_function
GO:0007566embryo implantationTASbiological_process
GO:0004925prolactin receptor activityNASmolecular_function
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0007171activation of transmembrane receptor protein tyrosIDAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0007595lactationNASbiological_process
GO:0043066negative regulation of apoptotic processNASbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0042978ornithine decarboxylase activator activityNASmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0031904endosome lumenTAScellular_component
GO:0007166cell surface receptor signaling pathwayNASbiological_process
GO:0042977activation of JAK2 kinase activityNASbiological_process
GO:0042803protein homodimerization activityNASmolecular_function


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