Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRL_HUMAN
Description:prolactin [Source:HGNC Symbol;Acc:9445]
Location:chr6 p22.3
Node attribute:substrate; ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S179IYPVWsGLPSLHormone_1PhosphoSitePlus
S207CLRRDsHKIDNHormone_1PhosphoSitePlus
S194EESRLsAYYNLHormone_1PhosphoSitePlus
S163MELIVsQVHPEphosphoELM; RegPhos
S163MELIVsQVHPEHormone_1PhosphoSitePlus
S194EESRLsAYYNLphosphoELM; RegPhos
S207CLRRDsHKIDNPAK2phosphoELM; RegPhos

Dephosphorylation site
PRL_HUMAN do not have dephosphorylation site.

Mutation site
PRL_HUMAN do not have mutation site.

Differential expressed protein
PRL_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PRL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PRL_HUMANPRLR_HUMANligand -> receptorHPMR
PAK2_HUMANPRL_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANPRL_HUMANkinase -> substrateRegPhos
PRL_HUMANNK1R_HUMANotherKEGG
PRL_HUMANPRLR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005179hormone activityIEAmolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0007565female pregnancyNASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0007595lactationIEAbiological_process
GO:0040014regulation of multicellular organism growthIEPbiological_process
GO:0046427positive regulation of JAK-STAT cascadeIDAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0005148prolactin receptor bindingTASmolecular_function


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