Phosphorylation

Protein information

UniProt/SwissProt ID:	PRLR_HUMAN
Description:	prolactin receptor [Source:HGNC Symbol;Acc:9446]
Location:	chr5 p13.2
Node attribute:	receptor; PPI(target)

Position	PhosphoPeptide	Catalytic kinase	Source
S195	EFKILsLHPGQ	fn3	PhosphoSitePlus
S349	DPDTDsGRGSC		PhosphoSitePlus; phosphoELM
T415	GSKCStWPLPQ		PhosphoSitePlus; HPRD; phosphoELM
Y611	LGGLDyLDPAC		PhosphoSitePlus; HPRD; phosphoELM
S361	SPSLLsEKCEE		PhosphoSitePlus
Y509	AKPLDyVEIHK		PhosphoSitePlus
Y202	HPGQKyLVQVR	fn3	PhosphoSitePlus
S358	SCDSPsLLSEK		PhosphoSitePlus

PRLR_HUMAN do not have dephosphorylation site.

PRLR_HUMAN do not have mutation site.

PRLR_HUMAN is not differential expressed protein.

PRLR_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
PRL_HUMAN	PRLR_HUMAN	ligand -> receptor	HPMR
PRL_HUMAN	PRLR_HUMAN	other	KEGG

KEGG Pathway

KEGG ID	Pathway
hsa04630	Jak-STAT signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04080	Neuroactive ligand-receptor interaction

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0042110	T cell activation	NAS	biological_process
GO:0038161	prolactin signaling pathway	NAS	biological_process
GO:0017046	peptide hormone binding	IPI	molecular_function
GO:0006694	steroid biosynthetic process	NAS	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0016020	membrane	IEA	cellular_component
GO:0046872	metal ion binding	IEA	molecular_function
GO:0016021	integral to membrane	IEA	cellular_component
GO:0004896	cytokine receptor activity	IEA	molecular_function
GO:0007566	embryo implantation	TAS	biological_process
GO:0004925	prolactin receptor activity	NAS	molecular_function
GO:0060397	JAK-STAT cascade involved in growth hormone signal	TAS	biological_process
GO:0007171	activation of transmembrane receptor protein tyros	IDA	biological_process
GO:0009986	cell surface	IDA	cellular_component
GO:0007595	lactation	NAS	biological_process
GO:0043066	negative regulation of apoptotic process	NAS	biological_process
GO:0005576	extracellular region	IEA	cellular_component
GO:0042978	ornithine decarboxylase activator activity	NAS	molecular_function
GO:0005886	plasma membrane	TAS	cellular_component
GO:0031904	endosome lumen	TAS	cellular_component
GO:0007166	cell surface receptor signaling pathway	NAS	biological_process
GO:0042977	activation of JAK2 kinase activity	NAS	biological_process
GO:0042803	protein homodimerization activity	NAS	molecular_function

Human Phosphorylation Mediated
Signaling Transduction Network