| UniProt/SwissProt ID: | PRLHR_HUMAN |
| Description: | prolactin releasing hormone receptor [Source:HGNC Symbol;Acc:4464] |
| Location: | chr10 q26.11 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S244 | LVILLsYVRVS | 7tm_1; TM | PhosphoSitePlus |
| Y120 | PLTLAyAFEPR | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| PRLHR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000358167 | A307V | COSMIC | Skin Cancer | 21984974 | ENSP00000358167 | A288D | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PRLHR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PRLHR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PRRP_HUMAN | PRLHR_HUMAN | ligand -> receptor | HPMR |
| PRLHR_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| PRLHR_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| CATG_HUMAN | PRLHR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007565 | female pregnancy | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0004983 | neuropeptide Y receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0042445 | hormone metabolic process | IEA | biological_process |
| GO:0008188 | neuropeptide receptor activity | TAS | molecular_function |
| GO:0007218 | neuropeptide signaling pathway | TAS | biological_process |
| GO:0007631 | feeding behavior | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |