| UniProt/SwissProt ID: | PRG2_HUMAN |
| Description: | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) [Source:HGNC Symbol;Acc:9362] |
| Location: | chr11 q12.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| PRG2_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| PRG2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000433016 | R179C | BIOMART | Colorectal Cancer | 21930507, 21930502 | ENSP00000312134 | R179C | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000312134 | R179C | HPI | Colorectal Cancer | 16959974 |
| Differential expressed protein |
| PRG2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PRG2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| UHMK1_HUMAN | PRG2_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MK01_HUMAN | PRG2_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| MK03_HUMAN | PRG2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | PRG2_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | PRG2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05310 | Asthma |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006955 | immune response | IEA | biological_process |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0008201 | heparin binding | IEA | molecular_function |
| GO:0030133 | transport vesicle | IEA | cellular_component |
| GO:0042742 | defense response to bacterium | IEA | biological_process |
| GO:0030246 | carbohydrate binding | IEA | molecular_function |