Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PPR1B_HUMAN
Description:protein phosphatase 1, regulatory (inhibitor) subunit 1B [Source:HGNC Symbol;Acc:9287]
Location:chr17 q12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S46LSEHSsPEEEADARPP-32; Drc1-Sld2PhosphoSitePlus
Y116LRELGyPREEDDARPP-32; Drc1-Sld2; RNA_PhosphoSitePlus
S45RLSEHsSPEEECK2a2RegPhos
S78AYTPPsLKAVQDARPP-32; Drc1-Sld2; RNA_PhosphoSitePlus
T39NPCAYtPPSLKCDK5HPRD
S102NENQAsEEEDECSNK2A2HPRD
S102NENQAsEEEDECSNK2A1HPRD
T34RRRRPtPAMLFPKACaRegPhos
S45RLSEHsSPEEECSNK2A2HPRD
S45RLSEHsSPEEECSNK2A1HPRD
S198EPQRPsPSEPGRegPhos
S102NENQAsEEEDECK2a1-rsRegPhos
T34RRRRPtPAMLFPRKACAHPRD
Y74PNPCAyTPPSLDARPP-32; Drc1-Sld2; RNA_PhosphoSitePlus
S137EEEEDsQAEVLDARPP-32; Drc1-Sld2; RNA_PhosphoSitePlus
T34RRRRPtPAMLFDARPP-32; Drc1-Sld2PhosphoSitePlus
S45RLSEHsSPEEECK2a1RegPhos
S45RLSEHsSPEEECK2a1-rsRegPhos
T75NPCAYtPPSLKDARPP-32; Drc1-Sld2; RNA_PhosphoSitePlus
S102NENQAsEEEDEDARPP-32; Drc1-Sld2; RNA_PhosphoSitePlus
S12KKIQFsVPAPPDARPP-32; Drc1-Sld2PhosphoSitePlus
S102NENQAsEEEDECK2a2RegPhos
S102NENQAsEEEDECK2a1RegPhos
T34RRRRPtPAMLFPKA_alphaphosphoELM
T75NPCAYtPPSLKCDK5HPRD; RegPhos
T75NPCAYtPPSLKCDK_groupphosphoELM; RegPhos
S9RLSEHsSPEEECSNK2A2HPRD
S9RLSEHsSPEEECSNK2A1HPRD
S45RLSEHsSPEEEDARPP-32; Drc1-Sld2PhosphoSitePlus
S66NENQAsEEEDECSNK2A2HPRD
S66NENQAsEEEDECSNK2A1HPRD
S66GHHLKsKRPNPCK2a2RegPhos
S66GHHLKsKRPNPCK2a1RegPhos
T34RRRRPtPAMLFPKA_groupRegPhos
S66GHHLKsKRPNPCK2a1-rsRegPhos

Dephosphorylation site
PPR1B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000254079S52fs*28COSMICHepatocellular Carcinoma21822264
ENSP00000349688S52fs*28COSMICHepatocellular Carcinoma21822264

Differential expressed protein
PPR1B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PPR1B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK5_HUMANPPR1B_HUMANkinase -> substrateHPRD; RegPhos
CSK21_HUMANPPR1B_HUMANkinase -> substrateHPRD
KPCA_HUMANPPR1B_HUMANkinase -> substrateHPRD; NetPath
ZAGL2_HUMANPPR1B_HUMANkinase -> substrateRegPhos
CSK22_HUMANPPR1B_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05030Cocaine addiction
hsa04728Dopaminergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035556intracellular signal transductionIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0007621negative regulation of female receptivityIEAbiological_process
GO:0006469negative regulation of protein kinase activityTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0007165signal transductionTASbiological_process
GO:0004864protein phosphatase inhibitor activityIEAmolecular_function
GO:0005102receptor bindingIEAmolecular_function
GO:0005737cytoplasmNAScellular_component
GO:0004864protein phosphatase inhibitor activityTASmolecular_function
GO:0004860protein kinase inhibitor activityTASmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0008542visual learningIEAbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0008599protein phosphatase type 1 regulator activityTASmolecular_function


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