Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PPM1D_HUMAN
Description:protein phosphatase, Mg2+/Mn2+ dependent, 1D [Source:HGNC Symbol;Acc:9277]
Location:chr17 q23.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S570SLPTTsQRKNSPhosphoSitePlus
S46PRRSLsQPLPPPhosphoSitePlus
Y308PQKHKyIILGSPP2CPhosphoSitePlus
S85PDAGAsPAPSRHPRD
S40AEEKPsPRRSLPhosphoSitePlus
S565GAQPAsLPTTSPhosphoSitePlus
T517NLKMStPGQMKPhosphoSitePlus

Dephosphorylation site
PPM1D_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000306682C478*COSMICHead and Neck Cancer21798897
ENSP00000306682E447KCOSMICSkin Cancer21984974
ENSP00000306682W154RBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000306682V187LCOSMICHead and Neck Cancer21798893

Differential expressed protein
PPM1D_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PPM1D_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
P53_HUMANPPM1D_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0009617response to bacteriumIEAbiological_process
GO:0006470protein dephosphorylationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusTAScellular_component
GO:0000086G2/M transition of mitotic cell cycleIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0004722protein serine/threonine phosphatase activityIDAmolecular_function
GO:0003824catalytic activityIEAmolecular_function
GO:0035970peptidyl-threonine dephosphorylationIDAbiological_process
GO:0009314response to radiationTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23