| UniProt/SwissProt ID: | PPM1D_HUMAN |
| Description: | protein phosphatase, Mg2+/Mn2+ dependent, 1D [Source:HGNC Symbol;Acc:9277] |
| Location: | chr17 q23.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S570 | SLPTTsQRKNS | PhosphoSitePlus | |
| S46 | PRRSLsQPLPP | PhosphoSitePlus | |
| Y308 | PQKHKyIILGS | PP2C | PhosphoSitePlus |
| S85 | PDAGAsPAPSR | HPRD | |
| S40 | AEEKPsPRRSL | PhosphoSitePlus | |
| S565 | GAQPAsLPTTS | PhosphoSitePlus | |
| T517 | NLKMStPGQMK | PhosphoSitePlus | |
| Dephosphorylation site |
| PPM1D_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000306682 | C478* | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000306682 | E447K | COSMIC | Skin Cancer | 21984974 | ENSP00000306682 | W154R | BIOMART | chronic lymphocytic leukemia | 21930507, 21930502 | ENSP00000306682 | V187L | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| PPM1D_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PPM1D_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P53_HUMAN | PPM1D_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04115 | p53 signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0009617 | response to bacterium | IEA | biological_process |
| GO:0006470 | protein dephosphorylation | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0000086 | G2/M transition of mitotic cell cycle | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0004722 | protein serine/threonine phosphatase activity | IDA | molecular_function |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0035970 | peptidyl-threonine dephosphorylation | IDA | biological_process |
| GO:0009314 | response to radiation | TAS | biological_process |