Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PPLA_HUMAN
Description:phospholamban [Source:HGNC Symbol;Acc:9080]
Location:chr6 q22.31
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T17IRRAStIEMPQCCDPKphosphoELM; RegPhos; SysPTM
S16AIRRAsTIEMPPKA_groupphosphoELM; RegPhos
S16AIRRAsTIEMPPRKACAHPRD
S16AIRRAsTIEMPPKACaRegPhos
S16AIRRAsTIEMPphosphoELM
S16AIRRAsTIEMPPhospholamban; BatA; BacuPhosphoSitePlus
T17IRRAStIEMPQHPRD; phosphoELM; RegPhos; SysPTM
T17IRRAStIEMPQPhospholamban; BatA; BacuPhosphoSitePlus; SysPTM
T17IRRAStIEMPQCaMK_groupRegPhos; SysPTM

Dephosphorylation site
PPLA_HUMAN do not have dephosphorylation site.

Mutation site
PPLA_HUMAN do not have mutation site.

Differential expressed protein
PPLA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PPLA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPPLA_HUMANkinase -> substrateRegPhos
KCC4_HUMANPPLA_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANPPLA_HUMANkinase -> substrateKEGG; HPRD
PPLA_HUMANAT2A1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05414Dilated cardiomyopathy
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0086092regulation of the force of heart contraction by caIEAbiological_process
GO:0010880regulation of release of sequestered calcium ion iIEAbiological_process
GO:0016529sarcoplasmic reticulumIEAcellular_component
GO:0005246calcium channel regulator activityIEAmolecular_function
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0060314regulation of ryanodine-sensitive calcium-release IEAbiological_process
GO:0008015blood circulationNASbiological_process
GO:0086023adrenergic receptor signaling pathway involved in IEAbiological_process
GO:0031966mitochondrial membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0090279regulation of calcium ion importIEAbiological_process
GO:0006816calcium ion transportIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0042030ATPase inhibitor activityIEAmolecular_function
GO:0010881regulation of cardiac muscle contraction by regulaIEAbiological_process
GO:0002026regulation of the force of heart contractionIEAbiological_process
GO:1901077regulation of relaxation of muscleIEAbiological_process
GO:0045822negative regulation of heart contractionIEAbiological_process
GO:0048738cardiac muscle tissue developmentIEAbiological_process
GO:0086004regulation of cardiac muscle cell contractionIEAbiological_process
GO:0051924regulation of calcium ion transportISSbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0008016regulation of heart contractionIEAbiological_process
GO:0031982vesicleIEAcellular_component


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