Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AT2A1_HUMAN
Description:ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [Source:HGNC Symbol;Acc:811]
Location:chr16 p11.2
Node attribute:PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S170ILAIKsTTLRVE1-E2_ATPasePhosphoSitePlus
Y527IDRCNyVRVGTHydrolasePhosphoSitePlus
Y497KSMSVyCSPAKHydrolasePhosphoSitePlus
S261FGEQLsKVISLTM; E1-E2_ATPasePhosphoSitePlus
S731VAKTAsEMVLAPhosphoSitePlus
T484MKKEFtLEFSRHydrolasePhosphoSitePlus
S722GIAMGsGTAVAPhosphoSitePlus
T742DDNFStIVAAVPhosphoSitePlus
T625RVIMItGDNKGHydrolasePhosphoSitePlus
S186TGESVsVIKHTE1-E2_ATPasePhosphoSitePlus
T724AMGSGtAVAKTPhosphoSitePlus
T446TETALtTLVEKHPRD

Dephosphorylation site
AT2A1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000349595G704CCOSMICOvarian Cancer21720365
ENSP00000349595E381KCOSMICOvarian Cancer21720365
ENSP00000349595V223ECOSMICSkin Cancer21984974
ENSP00000378879G704CTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000349595Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
AT2A1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PPLA_HUMANAT2A1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa04972Pancreatic secretion
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0016021integral to membraneNAScellular_component
GO:0019829cation-transporting ATPase activityIEAmolecular_function
GO:0031448positive regulation of fast-twitch skeletal muscleIDAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005509calcium ion bindingIMPmolecular_function
GO:0006812cation transportIEAbiological_process
GO:0045988negative regulation of striated muscle contractionIMPbiological_process
GO:0031674I bandIDAcellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0070509calcium ion importIMPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005793endoplasmic reticulum-Golgi intermediate compartmeISScellular_component
GO:0031095platelet dense tubular network membraneTAScellular_component
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0051659maintenance of mitochondrion locationIMPbiological_process
GO:0034220ion transmembrane transportTASbiological_process
GO:0005388calcium-transporting ATPase activityIDAmolecular_function
GO:0070059intrinsic apoptotic signaling pathway in response IMPbiological_process
GO:0032471reduction of endoplasmic reticulum calcium ion conIMPbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0016020membraneISScellular_component
GO:0032470elevation of endoplasmic reticulum calcium ion conIMPbiological_process
GO:0008637apoptotic mitochondrial changesIMPbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0006816calcium ion transportIMPbiological_process
GO:0033017sarcoplasmic reticulum membraneTAScellular_component
GO:0016529sarcoplasmic reticulumNAScellular_component
GO:0055085transmembrane transportTASbiological_process
GO:0090076relaxation of skeletal muscleIDAbiological_process
GO:0031673H zoneIDAcellular_component
GO:0006200ATP catabolic processISSbiological_process
GO:0005388calcium-transporting ATPase activityIEAmolecular_function
GO:0006942regulation of striated muscle contractionIMPbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0051561elevation of mitochondrial calcium ion concentratiIMPbiological_process
GO:0006754ATP biosynthetic processIEAbiological_process
GO:0034704calcium channel complexICcellular_component
GO:0048471perinuclear region of cytoplasmISScellular_component
GO:0034976response to endoplasmic reticulum stressIMPbiological_process


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