| UniProt/SwissProt ID: | PO2F2_HUMAN |
| Description: | POU class 2 homeobox 2 [Source:HGNC Symbol;Acc:9213] |
| Location: | chr19 q13.2 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T306 | RTSIEtNVRFA | Homeobox | PhosphoSitePlus |
| S250 | EALNLsFKNMC | Pou | PhosphoSitePlus |
| S234 | EALNLsFKNMC | HPRD | |
| S55 | SPFSVsPTGPS | PhosphoSitePlus | |
| Dephosphorylation site |
| PO2F2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000373992 | R280W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000373992 | D275E | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000373992 | S433R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PO2F2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PO2F2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PO2F2_HUMAN | MYC_HUMAN | TF -> target gene | TRANSFAC |
| PO2F2_HUMAN | IL2_HUMAN | TF -> target gene | TRANSFAC |
| PO2F2_HUMAN | IL5_HUMAN | TF -> target gene | TRANSFAC |
| PO2F2_HUMAN | HBG1_HUMAN | TF -> target gene | TRANSFAC |
| PO2F2_HUMAN | IGLL5_HUMAN | TF -> target gene | TRANSFAC |
| PO2F2_HUMAN | LYN_HUMAN | TF -> target gene | TRANSFAC |
| PO2F2_HUMAN | H2B1J_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| PO2F2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0048305 | immunoglobulin secretion | IEA | biological_process |
| GO:0019904 | protein domain specific binding | IEA | molecular_function |
| GO:0002335 | mature B cell differentiation | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0002380 | immunoglobulin secretion involved in immune respon | IEA | biological_process |
| GO:0048469 | cell maturation | IEA | biological_process |
| GO:0006959 | humoral immune response | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |