Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLXB1_HUMAN
Description:plexin B1 [Source:HGNC Symbol;Acc:9103]
Location:chr3 p21.31
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1667DLVAQyVAKNPPlexin_cytoplPhosphoSitePlus
T1870VPGERtPMLEDPlexin_cytoplPhosphoSitePlus
Y1708VGEPLyMLFRGPlexin_cytoplPhosphoSitePlus
Y1732TGKAKyTLNDNPlexin_cytoplPhosphoSitePlus
S1902RPRRGsLRGGEPlexin_cytoplPhosphoSitePlus

Dephosphorylation site
PLXB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000351338A639VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000296440D1891VSjoblom2006, HPIBreast Cancer16959974
ENSP00000395987*730YCOSMICLung Cancer18948947
ENSP00000351338D1891VSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000351338Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
PLXB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SEM4D_HUMANPLXB1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033689negative regulation of osteoblast proliferationISSbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaISSbiological_process
GO:0002116semaphorin receptor complexIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005576extracellular regionIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0030215semaphorin receptor bindingTASmolecular_function
GO:0048812neuron projection morphogenesisIEAbiological_process
GO:0016477cell migrationNASbiological_process
GO:0005887integral to plasma membraneNAScellular_component
GO:0071526semaphorin-plexin signaling pathwayIDAbiological_process
GO:0032321positive regulation of Rho GTPase activityIEAbiological_process
GO:0051493regulation of cytoskeleton organizationIDAbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0043931ossification involved in bone maturationIEAbiological_process
GO:0033689negative regulation of osteoblast proliferationIEAbiological_process
GO:0043931ossification involved in bone maturationISSbiological_process
GO:0017154semaphorin receptor activityTASmolecular_function
GO:1900220semaphorin-plexin signaling pathway involved in boIEAbiological_process
GO:0032794GTPase activating protein bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:1900220semaphorin-plexin signaling pathway involved in boISSbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0048812neuron projection morphogenesisISSbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0004872receptor activityTASmolecular_function
GO:0035556intracellular signal transductionNASbiological_process
GO:0050772positive regulation of axonogenesisIEAbiological_process
GO:0032794GTPase activating protein bindingISSmolecular_function
GO:0032321positive regulation of Rho GTPase activityISSbiological_process
GO:0004888transmembrane signaling receptor activityNASmolecular_function
GO:0008360regulation of cell shapeIDAbiological_process
GO:0005515protein bindingIEAmolecular_function


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