| UniProt/SwissProt ID: | PIDD_HUMAN |
| Description: | p53-induced death domain protein [Source:HGNC Symbol;Acc:16491] |
| Location: | chr11 p15.5 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T4 | __MAAtVEGPE | PhosphoSitePlus | |
| T788 | ETGFLtQSNLL | PhosphoSitePlus | |
| Y814 | HLGVSyREVQR | Death | PhosphoSitePlus |
| T485 | FPPGAtEEPRR | HPRD | |
| T485 | FPPGAtEEPRR | ZU5 | PhosphoSitePlus |
| Dephosphorylation site |
| PIDD_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000337797 | P210L | COSMIC | Skin Cancer | 21984974 | ENSP00000416801 | D200H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000337797 | M493V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000337797 | D200H | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| PIDD_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PIDD_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P53_HUMAN | PIDD_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04115 | p53 signaling pathway |
| hsa04064 | NF-kappa B signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005737 | cytoplasm | IMP | cellular_component |
| GO:0005634 | nucleus | IMP | cellular_component |
| GO:0006974 | response to DNA damage stimulus | IDA | biological_process |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0005123 | death receptor binding | TAS | molecular_function |
| GO:0043066 | negative regulation of apoptotic process | IMP | biological_process |
| GO:0006977 | DNA damage response, signal transduction by p53 cl | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |