| UniProt/SwissProt ID: | PHS_HUMAN |
| Description: | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha [Source:HGNC Symbol;Acc:8646] |
| Location: | chr10 q22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S9 | KAHRLsAEERD | HPRD | |
| Dephosphorylation site |
| PHS_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000299299 | I34M | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000299299 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 3.4 | 18646787 | ENSP00000299299 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.67 | 20739354 | ENSP00000299299 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.67 | 20739354 |
| Hyperphosphorylation site |
| PHS_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KKCC1_HUMAN | PHS_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | PHS_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK2_HUMAN | PHS_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PHS_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051289 | protein homotetramerization | IEA | biological_process |
| GO:0003713 | transcription coactivator activity | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0051291 | protein heterooligomerization | IEA | biological_process |
| GO:0008124 | 4-alpha-hydroxytetrahydrobiopterin dehydratase act | EXP | molecular_function |
| GO:0006559 | L-phenylalanine catabolic process | TAS | biological_process |
| GO:0006729 | tetrahydrobiopterin biosynthetic process | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004505 | phenylalanine 4-monooxygenase activity | IEA | molecular_function |
| GO:0034641 | cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0043496 | regulation of protein homodimerization activity | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |