Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PGM1_HUMAN
Description:phosphoglucomutase 1 [Source:HGNC Symbol;Acc:8905]
Location:chr1 p31.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y353TKIALyETPTGPGM_PMM_IIIPhosphoSitePlus
Y353TKIALyETPTGHPRD; RegPhos
T348RVASAtKIALYPGM_PMM_IIIPhosphoSitePlus
T513GSAGAtIRLYIPGM_PMM_IVPhosphoSitePlus
Y66GDGRFyMKEAIPGM_PMM_IPhosphoSitePlus
T507FRLSGtGSAGAHPRD
S117IILTAsHNPGGPGM_PMM_IPhosphoSitePlus
Y521LYIDSyEKDVAPGM_PMM_IVPhosphoSitePlus
T115GGIILtASHNPPGM_PMM_IPhosphoSitePlus; SysPTM
S369NLMDAsKLSLCPGM_PMM_IIIPhosphoSitePlus
Y12VKTQAyQDQKPPhosphoSitePlus
S346LDRVAsATKIAPGM_PMM_IIIPhosphoSitePlus
S369NLMDAsKLSLCHPRD
S505IVFRLsGTGSAPGM_PMM_IVPhosphoSitePlus
S505IVFRLsGTGSAHPRD
S520RLYIDsYEKDVPGM_PMM_IVPhosphoSitePlus
S117IILTAsHNPGGHPRD; phosphoELM; RegPhos
S408ATRKQsVEDILPGM_PMM_IIIPhosphoSitePlus
Y232GVVGPyVKKILPGM_PMM_IIPhosphoSitePlus
T467NDKVYtVEKADPGM_PMM_IVPhosphoSitePlus
T19DQKPGtSGLRKPGM_PMM_IPhosphoSitePlus
T467NDKVYtVEKADPAK1phosphoELM; RegPhos
Y195DSVEAyATMLRPGM_PMM_IIPhosphoSitePlus
T115GGIILtASHNPHPRD; phosphoELM; RegPhos; SysPTM
S509LSGTGsAGATIPGM_PMM_IVPhosphoSitePlus
T197VEAYAtMLRSIPGM_PMM_IIPhosphoSitePlus
T507FRLSGtGSAGAPGM_PMM_IVPhosphoSitePlus
T19DQKPGtSGLRKHPRD
S338RSMPTsGALDRPGM_PMM_IIIPhosphoSitePlus
S134IKFNIsNGGPAPGM_PMM_IPhosphoSitePlus

Dephosphorylation site
PGM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360125S213YCOSMICHead and Neck Cancer21798893
ENSP00000360125A397VCOSMICOvarian Cancer20826764
ENSP00000360125R343WCOSMICSkin Cancer21984974
ENSP00000360125P321LCOSMICRenal Cancer20054297

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000360125hepatitis C virusNormal vs. CancertissueDown0.418715028
ENSP00000360125Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.418646787
ENSP00000360125Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.1518646787
ENSP00000360125Gastric CancerMetastasiscell lineDown0.3717022644
ENSP00000360125colorectal cancerNormal vs. CancertissueDown0.4619098285
ENSP00000360125Gastric CancerMetastasiscell lineDown0.3717022644
ENSP00000360125Renal CancerNormal vs. CancertissueUp1.1-3.4 12923786
ENSP00000360125Pancreatic CancerNormal vs. CancertissueDown0.515526344

Hyperphosphorylation site
PGM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPGM1_HUMANkinase -> substrateRegPhos
PKN1_HUMANPGM1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CSK21_HUMANPGM1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00520Amino sugar and nucleotide sugar metabolism
hsa00030Pentose phosphate pathway
hsa01100Metabolic pathways
hsa00010Glycolysis / Gluconeogenesis
hsa00052Galactose metabolism
hsa00230Purine metabolism
hsa00500Starch and sucrose metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006094gluconeogenesisTASbiological_process
GO:0006006glucose metabolic processIEAbiological_process
GO:0006006glucose metabolic processNASbiological_process
GO:0016868intramolecular transferase activity, phosphotransfIEAmolecular_function
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0006096glycolysisTASbiological_process
GO:0005829cytosolIBAcellular_component
GO:0005737cytoplasmNAScellular_component
GO:0005978glycogen biosynthetic processIBAbiological_process
GO:0005980glycogen catabolic processTASbiological_process
GO:0004614phosphoglucomutase activityIDAmolecular_function
GO:0004614phosphoglucomutase activityIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0019388galactose catabolic processIBAbiological_process
GO:0015629actin cytoskeletonIDAcellular_component


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