| UniProt/SwissProt ID: | PERE_HUMAN |
| Description: | eosinophil peroxidase [Source:HGNC Symbol;Acc:3423] |
| Location: | chr17 q22 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S672 | SRISLsRIICD | An_peroxidase | PhosphoSitePlus |
| S74 | PMDLLsYFKQP | PhosphoSitePlus | |
| Y431 | VQIITyRDFLP | An_peroxidase | PhosphoSitePlus |
| S322 | SEVSLsLRLRN | An_peroxidase | PhosphoSitePlus |
| S66 | RLRSGsASPMD | PhosphoSitePlus | |
| Y75 | MDLLSyFKQPV | PhosphoSitePlus | |
| S670 | ALSRIsLSRII | An_peroxidase | PhosphoSitePlus |
| Dephosphorylation site |
| PERE_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000225371 | R645* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000225371 | Q339E | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000225371 | Q662K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000225371 | S365L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000225371 | R645* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000225371 | Q662K | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PERE_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PERE_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PERE_HUMAN | EPOR_HUMAN | ligand -> receptor | HPMR |
| PERE_HUMAN | EPOR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05310 | Asthma |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0072677 | eosinophil migration | IEA | biological_process |
| GO:0032714 | negative regulation of interleukin-5 production | IEA | biological_process |
| GO:0006979 | response to oxidative stress | IEA | biological_process |
| GO:0032753 | positive regulation of interleukin-4 production | IEA | biological_process |
| GO:0020037 | heme binding | IEA | molecular_function |
| GO:0002215 | defense response to nematode | IEA | biological_process |
| GO:0032693 | negative regulation of interleukin-10 production | IEA | biological_process |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0004601 | peroxidase activity | IEA | molecular_function |
| GO:0042744 | hydrogen peroxide catabolic process | IEA | biological_process |