| UniProt/SwissProt ID: | PER2_HUMAN |
| Description: | period circadian clock 2 [Source:HGNC Symbol;Acc:8846] |
| Location: | chr2 q37.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T781 | PGLRNtSGIDS | PhosphoSitePlus | |
| S662 | PGKAEsVASLT | PhosphoSitePlus; RegPhos | |
| S668 | VASLTsQCSYS | CSNK1E | HPRD |
| S1109 | GSIDSsENNHK | Period_C | PhosphoSitePlus |
| S810 | RDSSEsTGSGG | PhosphoSitePlus | |
| S696 | VEDAAsGPESL | RegPhos | |
| S977 | AMGRAsPPLFQ | CSNK1D | HPRD |
| S700 | ASGPEsLDCLA | RegPhos | |
| S782 | GLRNTsGIDSP | PhosphoSitePlus | |
| S714 | LACGLsQEKEP | RegPhos | |
| S540 | EQKKKsVTEMQ | RegPhos | |
| S668 | VASLTsQCSYS | PhosphoSitePlus | |
| S533 | HYSHEsGEQKK | RegPhos | |
| S665 | AESVAsLTSQC | PhosphoSitePlus | |
| S945 | EMASAsQPEFP | RegPhos | |
| S530 | NRSHYsHESGE | RegPhos | |
| S1108 | FGSIDsSENNH | Period_C | PhosphoSitePlus |
| S977 | AMGRAsPPLFQ | RegPhos | |
| S766 | YLQERsKGQPS | RegPhos | |
| S662 | PGKAEsVASLT | CK1e(CK1 epsilon | RegPhos |
| T864 | FPAPGtVAAPP | RegPhos | |
| S665 | AESVAsLTSQC | CSNK1E | HPRD |
| S662 | PGKAEsVASLT | CK1e | RegPhos |
| S786 | TSGIDsPWKKT | PhosphoSitePlus | |
| S527 | KTKNRsHYSHE | RegPhos | |
| S977 | AMGRAsPPLFQ | CK1d | RegPhos |
| S674 | QCSYSsTIVHV | CSNK1E | HPRD |
| S771 | SKGQPsERTAP | RegPhos | |
| S1105 | SKYFGsIDSSE | Period_C | PhosphoSitePlus |
| S1124 | TGMEEsEHFIK | RegPhos | |
| S662 | PGKAEsVASLT | CK1_epsilon | phosphoELM |
| S662 | PGKAEsVASLT | CSNK1E | HPRD |
| S671 | LTSQCsYSSTI | CSNK1E | HPRD |
| Dephosphorylation site |
| PER2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000254657 | K553R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000254657 | Y1102* | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000254657 | L823V | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 |
| Differential expressed protein |
| PER2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PER2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KC1E_HUMAN | PER2_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KC1D_HUMAN | PER2_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | PER2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05168 | Herpes simplex infection |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa04710 | Circadian rhythm - mammal |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0000988 | protein binding transcription factor activity | IEA | molecular_function |
| GO:0007623 | circadian rhythm | IEA | biological_process |