Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PENK_HUMAN
Description:proenkephalin [Source:HGNC Symbol;Acc:8831]
Location:chr8 q12.1
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S129EEANGsEILAKPhosphoSitePlus
S196RGLKRsPQLEDPhosphoSitePlus; HPRD
S251EGESYsKEVPEHPRD

Dephosphorylation site
PENK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000324248D115NCOSMICHead and Neck Cancer21984974
ENSP00000324248L69QCOSMICHead and Neck Cancer21798893
ENSP00000324248P77SCOSMICMelanoma21499247
ENSP00000324248R216GCOSMICOvarian Cancer21720365
ENSP00000324248E258QCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000400894Brain CancerNormal vs. CancertissueDown0.3818056677

Hyperphosphorylation site
PENK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PENK_HUMANOGFR_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
PENK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019233sensory perception of painIEAbiological_process
GO:0007218neuropeptide signaling pathwayIEAbiological_process
GO:0001515opioid peptide activityIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0001662behavioral fear responseIEAbiological_process
GO:0005184neuropeptide hormone activityTASmolecular_function
GO:0007610behaviorIEAbiological_process
GO:0005576extracellular regionIEAcellular_component


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