| UniProt/SwissProt ID: | PENK_HUMAN |
| Description: | proenkephalin [Source:HGNC Symbol;Acc:8831] |
| Location: | chr8 q12.1 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S129 | EEANGsEILAK | PhosphoSitePlus | |
| S196 | RGLKRsPQLED | PhosphoSitePlus; HPRD | |
| S251 | EGESYsKEVPE | HPRD | |
| Dephosphorylation site |
| PENK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000324248 | D115N | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000324248 | L69Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000324248 | P77S | COSMIC | Melanoma | 21499247 | ENSP00000324248 | R216G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000324248 | E258Q | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000400894 | Brain Cancer | Normal vs. Cancer | tissue | Down | 0.38 | 18056677 |
| Hyperphosphorylation site |
| PENK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PENK_HUMAN | OGFR_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| PENK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019233 | sensory perception of pain | IEA | biological_process |
| GO:0007218 | neuropeptide signaling pathway | IEA | biological_process |
| GO:0001515 | opioid peptide activity | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0001662 | behavioral fear response | IEA | biological_process |
| GO:0005184 | neuropeptide hormone activity | TAS | molecular_function |
| GO:0007610 | behavior | IEA | biological_process |
| GO:0005576 | extracellular region | IEA | cellular_component |