| UniProt/SwissProt ID: | PEBP1_HUMAN |
| Description: | phosphatidylethanolamine binding protein 1 [Source:HGNC Symbol;Acc:8630] |
| Location: | chr12 q24.23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S153 | KFKVAsFRKKY | PBP | PhosphoSitePlus |
| S98 | KGNDIsSGTVL | PBP | PhosphoSitePlus |
| T42 | LGKVLtPTQVK | HPRD; SysPTM | |
| T51 | VKNRPtSISWD | HPRD | |
| S153 | KFKVAsFRKKY | PKCd(PKC delta | RegPhos |
| Y125 | YVWLVyEQDRP | HPRD | |
| S104 | SGTVLsDYVGS | PBP | PhosphoSitePlus |
| S60 | WDGLDsGKLYT | PBP | PhosphoSitePlus |
| S153 | KFKVAsFRKKY | PKC_delta | phosphoELM |
| S99 | GNDISsGTVLS | PBP | PhosphoSitePlus |
| Y81 | RKDPKyREWHH | PBP | PhosphoSitePlus |
| Y120 | TGLHRyVWLVY | PBP | PhosphoSitePlus |
| S153 | KFKVAsFRKKY | PKCb | RegPhos |
| S153 | KFKVAsFRKKY | PKCg | RegPhos |
| S153 | KFKVAsFRKKY | PKCd | RegPhos |
| S153 | KFKVAsFRKKY | PKCz | RegPhos |
| Y106 | TVLSDyVGSGP | PBP | PhosphoSitePlus |
| S54 | RPTSIsWDGLD | PBP | PhosphoSitePlus |
| S75 | DPDAPsRKDPK | PBP | PhosphoSitePlus |
| S153 | KFKVAsFRKKY | PKCa(PKC alpha | RegPhos |
| Y125 | YVWLVyEQDRP | PBP | PhosphoSitePlus |
| Y64 | DSGKLyTLVLT | PBP | PhosphoSitePlus |
| S99 | GNDISsGTVLS | HPRD | |
| S54 | RPTSIsWDGLD | HPRD; RegPhos | |
| S153 | KFKVAsFRKKY | PKC_alpha | phosphoELM |
| T42 | LGKVLtPTQVK | PBP | PhosphoSitePlus; SysPTM |
| S153 | KFKVAsFRKKY | PKCa | RegPhos |
| S52 | KNRPTsISWDG | PBP | PhosphoSitePlus; SysPTM |
| Y169 | VAGTCyQAEWD | PBP | PhosphoSitePlus |
| S52 | KNRPTsISWDG | HPRD; phosphoELM; RegPhos; SysPTM | |
| S185 | LYEQLsGK___ | PhosphoSitePlus | |
| T28 | HPLHVtYAGAA | PBP | PhosphoSitePlus |
| Y120 | TGLHRyVWLVY | HPRD | |
| Y181 | YVPKLyEQLSG | PhosphoSitePlus; SysPTM | |
| S153 | KFKVAsFRKKY | PRKCZ | HPRD |
| S153 | KFKVAsFRKKY | PRKCA | HPRD |
| S153 | KFKVAsFRKKY | PRKCB | HPRD |
| S153 | KFKVAsFRKKY | PRKCD | HPRD |
| S153 | KFKVAsFRKKY | PRKCG | HPRD |
| T51 | VKNRPtSISWD | PBP | PhosphoSitePlus |
| Y176 | AEWDDyVPKLY | PhosphoSitePlus | |
| S13 | WSGPLsLQEVD | PhosphoSitePlus | |
| Dephosphorylation site |
| PEBP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000261313 | L58V | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000261313 | Non-small cell lung carcinoma | Metastasis | cell line | Down | 17537172 | ENSP00000261313 | hepatitis C virus | Normal vs. Cancer | tissue | Down | 0.2 | 18715028 | ENSP00000261313 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 2.1 | 18646787 | ENSP00000261313 | Gastric Cancer | Metastasis | cell line | Down | 0.48 | 17022644 | ENSP00000261313 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 1.4 | 19072117 | ENSP00000261313 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 1.6 | 19072117 | ENSP00000261313 | hepatitis B virus | Normal vs. Cancer | tissue | Down | 0.62 | 14654528 | ENSP00000261313 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 0.59 | 14654528 | ENSP00000261313 | hepatitis B virus | Normal vs. Cancer | tissue | Down | 0.38 | 15852300 | ENSP00000261313 | Neoplasms by Histologic Type | Cancer vs. Cancer | cell line | Up | 15750928 | ENSP00000261313 | Gastric Cancer | Metastasis | cell line | Down | 0.48 | 17022644 | ENSP00000261313 | Gastric Cancer | Normal vs. Cancer | tissue | Up | 4.4 | 19330469 | ENSP00000261313 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.5 | 20052998 | ENSP00000261313 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.3 | 20052998 | ENSP00000261313 | Breast Cancer | Metastasis | cell line | Down | 0.85 | 20052998 | ENSP00000261313 | Breast Cancer | Normal vs. Cancer | tissue | Up | 1.6 | 20087651 | ENSP00000261313 | Oral Cancer | Normal vs. Cancer | tissue | Down | 0.26 | 19691830 | ENSP00000261313 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Down | 0.19 | 15169874 | ENSP00000261313 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Down | 0.4 | 15169874 | ENSP00000261313 | Renal Cancer | Normal vs. Cancer | tissue | Down | 19164279 | ENSP00000261313 | Gastric Cancer | Normal vs. Cancer | tissue | Down | 20677338 | ENSP00000261313 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 56 | 19199705 |
| Hyperphosphorylation site |
| PEBP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | PEBP1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| ZAGL2_HUMAN | PEBP1_HUMAN | kinase -> substrate | RegPhos |
| KPCD_HUMAN | PEBP1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KPCG_HUMAN | PEBP1_HUMAN | kinase -> substrate | HPRD |
| KPCB_HUMAN | PEBP1_HUMAN | kinase -> substrate | HPRD |
| KPCZ_HUMAN | PEBP1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| PEBP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0008429 | phosphatidylethanolamine binding | TAS | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |