| UniProt/SwissProt ID: | PDE5A_HUMAN |
| Description: | phosphodiesterase 5A, cGMP-specific [Source:HGNC Symbol;Acc:8784] |
| Location: | chr4 q26 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S92 | PRADNsAPGTP | PhosphoSitePlus | |
| S60 | PTRKIsASEFD | PRKG1 | HPRD |
| S102 | PTRKIsASEFD | PKG1/cGK-I | phosphoELM |
| S102 | PTRKIsASEFD | PKA_group | phosphoELM; RegPhos |
| S102 | PTRKIsASEFD | PKG/cGK_group | phosphoELM |
| S869 | LINGEsGQAKR | PhosphoSitePlus | |
| S86 | CPLQQsPRADN | PhosphoSitePlus | |
| S102 | PTRKIsASEFD | PhosphoSitePlus; phosphoELM; RegPhos | |
| T137 | EQMPLtPPRFD | PhosphoSitePlus | |
| S102 | PTRKIsASEFD | PRKG1 | HPRD |
| S102 | PTRKIsASEFD | PKG_group | RegPhos |
| S102 | PTRKIsASEFD | PKG1 | RegPhos |
| Dephosphorylation site |
| PDE5A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264805 | K88N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000347046 | K130N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000347046 | R874Q | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| PDE5A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PDE5A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | PDE5A_HUMAN | kinase -> substrate | RegPhos |
| KGP1_HUMAN | PDE5A_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00230 | Purine metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0008270 | zinc ion binding | NAS | molecular_function |
| GO:0010613 | positive regulation of cardiac muscle hypertrophy | IEA | biological_process |
| GO:0043406 | positive regulation of MAP kinase activity | IEA | biological_process |
| GO:0046068 | cGMP metabolic process | IEA | biological_process |
| GO:0005575 | cellular_component | ND | cellular_component |
| GO:0055118 | negative regulation of cardiac muscle contraction | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0030553 | cGMP binding | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0004112 | cyclic-nucleotide phosphodiesterase activity | IEA | molecular_function |
| GO:0042130 | negative regulation of T cell proliferation | IEA | biological_process |
| GO:0055119 | relaxation of cardiac muscle | IEA | biological_process |
| GO:0009187 | cyclic nucleotide metabolic process | NAS | biological_process |
| GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity | IEA | molecular_function |
| GO:0046069 | cGMP catabolic process | IEA | biological_process |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0060282 | positive regulation of oocyte development | IEA | biological_process |