Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PCNA_HUMAN
Description:proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:8729]
Location:chr20 p12.3
Node attribute:PPI(target); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S261EDEEGs_____PhosphoSitePlus
Y211TFALRyLNFFTPCNA_CPhosphoSitePlus
Y250GHLKYyLAPKIHPRD; SysPTM

Dephosphorylation site
PCNA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368438I88VCOSMICLung Cancer
ENSP00000368458I88VCOSMICLung Cancer

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000368458Hepatocellular CarcinomaNormal vs. CancertissueUp9.115759316
ENSP00000368458Hepatocellular CarcinomaNormal vs. CancertissueUp317627933
ENSP00000368458Breast CancerTreatment (chemosensitive vs. paclitaxel-resistant)cell lineUp2.217487377
ENSP00000368458Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp3.518491314
ENSP00000368458hepatitis B virusTreatment (none vs tetracycline-treatment)cell lineUp219671925
ENSP00000368458Hepatocellular CarcinomaNormal vs. CancertissueUp18937283
ENSP00000368458Non-small cell lung carcinomaNormal vs. Cancercell lineUp15359725
ENSP00000368458Breast CancerMetastasiscell lineUp1.218582095
ENSP00000368458Breast CancerNormal vs. CancertissueUp>1020005186
ENSP00000368458Oral CancerNormal vs. CancertissueUp819691830
ENSP00000368458LeukemiaNormal vs. CancertissueUp15501966
ENSP00000368458acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp1117655343
ENSP00000368458Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueDown0.519422301
ENSP00000368458Gastric CancerNormal vs. CancertissueUp20677338
ENSP00000368458Uterine CancerNormal vs. Cancercell lineUp43015838902

Hyperphosphorylation site
PCNA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GA45G_HUMANPCNA_HUMANotherKEGG
RFX1_HUMANPCNA_HUMANTF -> target geneTRANSFAC
P53_HUMANPCNA_HUMANTF -> target geneTRANSFAC
E2F4_HUMANPCNA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03430Mismatch repair
hsa04110Cell cycle
hsa03030DNA replication
hsa03410Base excision repair
hsa05166HTLV-I infection
hsa03420Nucleotide excision repair

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006283transcription-coupled nucleotide-excision repairTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0032201telomere maintenance via semi-conservative replicaTASbiological_process
GO:0000083regulation of transcription involved in G1/S phaseTASbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0006260DNA replicationNASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0030971receptor tyrosine kinase bindingIPImolecular_function
GO:0043626PCNA complexIEAcellular_component
GO:0030337DNA polymerase processivity factor activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0019985translesion synthesisIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0008283cell proliferationTASbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0006284base-excision repairTASbiological_process
GO:0006289nucleotide-excision repairTASbiological_process
GO:0006281DNA repairNASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0032405MutLalpha complex bindingIDAmolecular_function
GO:0030896checkpoint clamp complexIEAcellular_component
GO:0046686response to cadmium ionIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0070557PCNA-p21 complexIDAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0032077positive regulation of deoxyribonuclease activityIDAbiological_process
GO:0006298mismatch repairIDAbiological_process
GO:0048015phosphatidylinositol-mediated signalingNASbiological_process
GO:0000723telomere maintenanceTASbiological_process
GO:0032139dinucleotide insertion or deletion bindingIDAmolecular_function
GO:0005663DNA replication factor C complexTAScellular_component
GO:0006275regulation of DNA replicationIEAbiological_process
GO:0006297nucleotide-excision repair, DNA gap fillingTASbiological_process
GO:0000701purine-specific mismatch base pair DNA N-glycosylaIDAmolecular_function
GO:0043596nuclear replication forkIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0033993response to lipidIEAbiological_process
GO:0000722telomere maintenance via recombinationTASbiological_process
GO:0000077DNA damage checkpointIEAbiological_process
GO:0015630microtubule cytoskeletonIDAcellular_component