Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	PCKGC_HUMAN
Description:	phosphoenolpyruvate carboxykinase 1 (soluble) [Source:HGNC Symbol;Acc:8724]
Location:	chr20 q13.31
Node attribute:	PPI(target); gene

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
Y557	LTPIGyIPKED		HPRD
T178	MTRMGtPVLEA	PEPCK	PhosphoSitePlus
Y595	EDIEKyLEDQV		HPRD
Y557	LTPIGyIPKED	PEPCK	PhosphoSitePlus
Y235	SFGSGyGGNSL	PEPCK	PhosphoSitePlus
S233	IISFGsGYGGN	PEPCK	PhosphoSitePlus

Dephosphorylation site

PCKGC_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000319814	A464V	BIOMART	Pancreatic Cancer	21930507, 21930502
ENSP00000319814	A325V	COSMIC	Melanoma	21499247
ENSP00000319814	G529C	COSMIC	Head and Neck Cancer	21798893

Differential expressed protein

Ensembl ID	Cancer name	Design	Sample	Change	Pubmed
ENSP00000319814	Renal Cancer	Normal vs. Cancer	tissue	Down	12923786
ENSP00000319814	Renal Cancer	Normal vs. Cancer	tissue	Down	19164279

Hyperphosphorylation site

PCKGC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
AAKG2_HUMAN	PCKGC_HUMAN	other	KEGG
FOXO1_HUMAN	PCKGC_HUMAN	TF -> target gene	KEGG

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa01100	Metabolic pathways
hsa00620	Pyruvate metabolism
hsa04920	Adipocytokine signaling pathway
hsa04910	Insulin signaling pathway
hsa04964	Proximal tubule bicarbonate reclamation
hsa00010	Glycolysis / Gluconeogenesis
hsa00020	Citrate cycle (TCA cycle)
hsa03320	PPAR signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0005737	cytoplasm	IEA	cellular_component
GO:0006107	oxaloacetate metabolic process	IEA	biological_process
GO:0044281	small molecule metabolic process	TAS	biological_process
GO:0030145	manganese ion binding	IDA	molecular_function
GO:0019003	GDP binding	IEA	molecular_function
GO:0006475	internal protein amino acid acetylation	IDA	biological_process
GO:0006629	lipid metabolic process	IEA	biological_process
GO:0017144	drug metabolic process	TAS	biological_process
GO:0030145	manganese ion binding	IEA	molecular_function
GO:0005737	cytoplasm	ISS	cellular_component
GO:0017076	purine nucleotide binding	IEA	molecular_function
GO:0042593	glucose homeostasis	ISS	biological_process
GO:0004611	phosphoenolpyruvate carboxykinase activity	IEA	molecular_function
GO:0032868	response to insulin stimulus	IDA	biological_process
GO:0046327	glycerol biosynthetic process from pyruvate	ISS	biological_process
GO:0014823	response to activity	IEA	biological_process
GO:0006094	gluconeogenesis	ISS	biological_process
GO:0006006	glucose metabolic process	IMP	biological_process
GO:0031406	carboxylic acid binding	IDA	molecular_function
GO:0005525	GTP binding	IEA	molecular_function
GO:0006006	glucose metabolic process	IEA	biological_process
GO:0005975	carbohydrate metabolic process	TAS	biological_process
GO:0042593	glucose homeostasis	IEA	biological_process
GO:0005525	GTP binding	IDA	molecular_function
GO:0005829	cytosol	TAS	cellular_component
GO:0031406	carboxylic acid binding	IEA	molecular_function
GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	ISS	molecular_function
GO:0000287	magnesium ion binding	IDA	molecular_function
GO:0046327	glycerol biosynthetic process from pyruvate	IEA	biological_process
GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	IEA	molecular_function

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network