Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PARD3_HUMAN
Description:par-3 partitioning defective 3 homolog (C. elegans) [Source:HGNC Symbol;Acc:16051]
Location:chr10 p11.21
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T481TSRDVtIGGSAPDZPhosphoSitePlus
S596VPLNDsGSAGLPDZPhosphoSitePlus
Y719ISHSLySGIEGPhosphoSitePlus; HPRD
Y388SPDSQyIDNRSPhosphoSitePlus; HPRD
T947DEGMEtLEEDTPhosphoSitePlus
S837RTKQFsDASQLPhosphoSitePlus
T534SLLRStKMEGTPDZPhosphoSitePlus
S1146VDSNRsTPSNHPhosphoSitePlus
S25HMKVFsLIQQADUF3534PhosphoSitePlus
S730LDESPsRNAALPhosphoSitePlus
Y1310EGPSNyDSYKKPhosphoSitePlus
Y199KKDENyRSLPRPhosphoSitePlus
S143LHVRRsSDPALDUF3534PhosphoSitePlus
Y1177DRRRTySFEQPPhosphoSitePlus; HPRD
S803AAISDsADCSLHPRD; phosphoELM
T895LESLQtAVAEVPhosphoSitePlus
S717RRISHsLYSGIPhosphoSitePlus; phosphoELM
S604AGLGVsVKGNRPDZPhosphoSitePlus
S667LRRSMsTEGNKPDZPhosphoSitePlus
S201DENYRsLPRDTPhosphoSitePlus
S695LKSPGsPPGPEPhosphoSitePlus; HPRD; phosphoELM
S887LGLKKsSSLESPhosphoSitePlus
S144HVRRSsDPALIHPRD; phosphoELM
Y1269GSRNGyLGGHGPhosphoSitePlus
T534SLLRStKMEGTHPRD
S533VSLLRsTKMEGPDZPhosphoSitePlus
S485VTIGGsAPIYVPDZPhosphoSitePlus
S221DNARSsLSASHPhosphoSitePlus
S529QEEVVsLLRSTPDZPhosphoSitePlus
S924RGCNEsFRAAIPhosphoSitePlus
S873DQKAGsPSRDVPhosphoSitePlus; HPRD; phosphoELM
T175PTRWStTAGFLPhosphoSitePlus; HPRD
Y1221QAQRQySSLPRPhosphoSitePlus
S973DQPSHsLERQMHPRD
Y489GSAPIyVKNILHPRD; phosphoELM
S1139RNSKPsPVDSNPhosphoSitePlus
S665ETLRRsMSTEGPDZPhosphoSitePlus
S1261NPRYSsYQGSRPhosphoSitePlus
Y1080ARERDyAEIQDPhosphoSitePlus; HPRD
S370QYEQLsQSEKNPhosphoSitePlus
S809ADCSLsPDVDPPhosphoSitePlus; HPRD; phosphoELM
S715RERRIsHSLYSPhosphoSitePlus; HPRD; phosphoELM
T1147DSNRStPSNHDPhosphoSitePlus
S827GFGRQsMSEKRPhosphoSitePlus
T579EDIVLtPDGTRPhosphoSitePlus; HPRD
Y1313SNYDSyKKVQDPhosphoSitePlus
S720SHSLYsGIEGLPhosphoSitePlus; phosphoELM
S1335QDVPPsPSQVAPhosphoSitePlus
S875KAGSPsRDVGPHPRD
S852TRKSKsMDLGIPhosphoSitePlus; HPRD; phosphoELM
T32IQQAVtRYRKADUF3534PhosphoSitePlus
Y377SEKNNyYSSRFPhosphoSitePlus
T1176EDRRRtYSFEQPhosphoSitePlus; HPRD
Y119SAFQPyQATSEDUF3534PhosphoSitePlus
S692CNELKsPGSPPPhosphoSitePlus; HPRD; phosphoELM
S166SSEEPsRKNPTPhosphoSitePlus
S144HVRRSsDPALIDUF3534PhosphoSitePlus
T668RRSMStEGNKRPDZPhosphoSitePlus
S1222AQRQYsSLPRQPhosphoSitePlus
Y378EKNNYySSRFSPhosphoSitePlus
S881RDVGPsLGLKKPhosphoSitePlus
S889LKKSSsLESLQPhosphoSitePlus; phosphoELM
Y933AIDKSyDKPAVPhosphoSitePlus
Y1244SWEQNySPGEGPhosphoSitePlus
S533VSLLRsTKMEGHPRD
S598LNDSGsAGLGVPDZPhosphoSitePlus
Y489GSAPIyVKNILPDZPhosphoSitePlus
S220RDNARsSLSASPhosphoSitePlus
S156LSTSVsDSNFSPhosphoSitePlus
S143LHVRRsSDPALHPRD; phosphoELM
T1347LNRLQtPEKGRPhosphoSitePlus
Y1104GGVSSyEGSMAPhosphoSitePlus
S523DLVGKsQEEVVPDZPhosphoSitePlus
S1178RRRTYsFEQPWPhosphoSitePlus
Y1127MMDALyAQVKKPhosphoSitePlus; HPRD; phosphoELM
S962RSGREsVSTASPhosphoSitePlus
S380NNYYSsRFSPDPhosphoSitePlus
S1312PSNYDsYKKVQPhosphoSitePlus
S807DSADCsLSPDVHPRD
Y1098DDELMyGGVSSPhosphoSitePlus
S383YSSRFsPDSQYPhosphoSitePlus; HPRD; phosphoELM
S379KNNYYsSRFSPPhosphoSitePlus
S386RFSPDsQYIDNPhosphoSitePlus
Y1321VQDPSyAPPKGPhosphoSitePlus
S174NPTRWsTTAGFPhosphoSitePlus; HPRD
S728EGLDEsPSRNAPhosphoSitePlus; HPRD; phosphoELM
S1337VPPSPsQVARLPhosphoSitePlus

Dephosphorylation site
PARD3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363908T648SBIOMARTBreast Cancer21930507, 21930502
ENSP00000363921R50GCOSMICHead and Neck Cancer21798893
ENSP00000363921T661SBIOMARTBreast Cancer21930507, 21930502
ENSP00000341844L108FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000363920L108FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000363926L108FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000311986T648SBIOMARTBreast Cancer21930507, 21930502
ENSP00000311986L108FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000340591L108FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000340591T661SBIOMARTBreast Cancer21930507, 21930502
ENSP00000363921L108FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000341844T661SBIOMARTBreast Cancer21930507, 21930502
ENSP00000363926T604SBIOMARTBreast Cancer21930507, 21930502
ENSP00000363908L108FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000363921R1156HCOSMICHead and Neck Cancer21798893
ENSP00000363920T661SBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
PARD3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PARD3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCI_HUMANPARD3_HUMANkinase -> substrateKEGG
PARD3_HUMANIGSF5_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04520Adherens junction
hsa04530Tight junction
hsa04144Endocytosis
hsa04080Neuroactive ligand-receptor interaction
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0034329cell junction assemblyTASbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0005819spindleIEAcellular_component
GO:0005913cell-cell adherens junctionIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0043234protein complexIEAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0032970regulation of actin filament-based processIEAbiological_process
GO:0006461protein complex assemblyTASbiological_process
GO:0005546phosphatidylinositol-4,5-bisphosphate bindingISSmolecular_function
GO:0012505endomembrane systemIEAcellular_component
GO:0044295axonal growth coneIEAcellular_component
GO:0005912adherens junctionIEAcellular_component
GO:0006612protein targeting to membraneIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0030054cell junctionTAScellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0019903protein phosphatase bindingIEAmolecular_function
GO:0070830tight junction assemblyIEAbiological_process
GO:0045216cell-cell junction organizationTASbiological_process
GO:0007409axonogenesisTASbiological_process
GO:0005923tight junctionISScellular_component
GO:0006612protein targeting to membraneISSbiological_process
GO:0090162establishment of epithelial cell polarityISSbiological_process
GO:0005547phosphatidylinositol-3,4,5-trisphosphate bindingIEAmolecular_function
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0045177apical part of cellIEAcellular_component
GO:0005080protein kinase C bindingIEAmolecular_function
GO:0032266phosphatidylinositol-3-phosphate bindingISSmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0051642centrosome localizationIEAbiological_process
GO:0090162establishment of epithelial cell polarityIEAbiological_process
GO:0044319wound healing, spreading of cellsIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0003383apical constrictionIEAbiological_process
GO:0007205protein kinase C-activating G-protein coupled receTASbiological_process
GO:0007163establishment or maintenance of cell polarityTASbiological_process
GO:0032266phosphatidylinositol-3-phosphate bindingIEAmolecular_function
GO:0005938cell cortexIEAcellular_component
GO:0005911cell-cell junctionIEAcellular_component
GO:0005546phosphatidylinositol-4,5-bisphosphate bindingIEAmolecular_function
GO:0005547phosphatidylinositol-3,4,5-trisphosphate bindingISSmolecular_function
GO:0070830tight junction assemblyISSbiological_process
GO:0008356asymmetric cell divisionTASbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0005911cell-cell junctionISScellular_component
GO:0060341regulation of cellular localizationIEAbiological_process


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