| UniProt/SwissProt ID: | PAI2_HUMAN |
| Description: | serpin peptidase inhibitor, clade B (ovalbumin), member 2 [Source:HGNC Symbol;Acc:8584] |
| Location: | chr18 q21.33 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T72 | AVTPMtPENFT | Serpin | PhosphoSitePlus |
| S296 | LNKWTsKDKMA | Serpin | PhosphoSitePlus |
| T69 | GANAVtPMTPE | Serpin | PhosphoSitePlus |
| Dephosphorylation site |
| PAI2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000299502 | N127S | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000401645 | N127S | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000401645 | E285K | COSMIC | Lung Cancer | ENSP00000299502 | E285K | COSMIC | Lung Cancer |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000401645 | Pancreatic Cancer | Normal vs. Cancer | tissue | Down | 0.05 | 16215274 | ENSP00000401645 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.22 | 20198662 |
| Hyperphosphorylation site |
| PAI2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | PAI2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| PAI2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042060 | wound healing | IEA | biological_process |
| GO:0010951 | negative regulation of endopeptidase activity | IBA | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0030162 | regulation of proteolysis | IBA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0043066 | negative regulation of apoptotic process | TAS | biological_process |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0042730 | fibrinolysis | TAS | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005576 | extracellular region | TAS | cellular_component |