| UniProt/SwissProt ID: | P2RY4_HUMAN |
| Description: | pyrimidinergic receptor P2Y, G-protein coupled, 4 [Source:HGNC Symbol;Acc:8542] |
| Location: | chrX q13.1 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S334 | RTAASsLALVS | PhosphoSitePlus; HPRD; phosphoELM | |
| S358 | QDSSCsTPRAD | PhosphoSitePlus | |
| S333 | PRTAAsSLALV | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| P2RY4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363643 | F75L | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| P2RY4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| P2RY4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P2RY4_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| P2RY4_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007204 | elevation of cytosolic calcium ion concentration | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0045028 | G-protein coupled purinergic nucleotide receptor a | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0030321 | transepithelial chloride transport | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0016324 | apical plasma membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007200 | phospholipase C-activating G-protein coupled recep | TAS | biological_process |
| GO:0045030 | UTP-activated nucleotide receptor activity | IEA | molecular_function |
| GO:0016323 | basolateral plasma membrane | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0015065 | uridine nucleotide receptor activity | TAS | molecular_function |