Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:OPSD_HUMAN
Description:rhodopsin [Source:HGNC Symbol;Acc:10012]
Location:chr3 q22.1
Node attribute:substrate; GPCR; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S334GDDEAsATVSKGRK1HPRD
S343SKTETsQVAPARHOK(GRK1RegPhos
S338ASATVsKTETSphosphoELM; RegPhos
S343SKTETsQVAPARHOKRegPhos
S343SKTETsQVAPARegPhos
S334GDDEAsATVSKGRK-1phosphoELM
S338ASATVsKTETSRHOK(GRK1RegPhos
S338ASATVsKTETSGRK-1phosphoELM
Y301KSAAIyNPVIY7tm_1; TMPhosphoSitePlus
S343SKTETsQVAGRK-1phosphoELM
S343SKTETsQVAphosphoELM
S334GDDEAsATVSKRHOK(GRK1RegPhos
S334GDDEAsATVSKPKCaRegPhos
Y136LAIERyVVVCK7tm_1PhosphoSitePlus
T336DEASAtVSKTEPKCaRegPhos
S334GDDEAsATVSKPRKCAHPRD
S338ASATVsKTETSRHOKRegPhos
S334GDDEAsATVSKRHOKRegPhos
T336DEASAtVSKTEPRKCAHPRD
T340ATVSKtETSQVHPRD; phosphoELM; RegPhos
S338ASATVsKTETSGRK1HPRD
S343SKTETsQVAGRK1HPRD
S334GDDEAsATVSKphosphoELM; RegPhos
Y306YNPVIyIMMNK7tm_1; TMPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S343TVSKTETsQVAPAPPP2CAHPRD
S334PLGDDEAsATVSKTEHPRD
S338DEASATVsKTETSQVPPP2CAHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296271A260TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000296271E249*COSMICSkin Cancer21984974

Differential expressed protein
OPSD_HUMAN is not differential expressed protein.

Hyperphosphorylation site
OPSD_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
OPSD_HUMANGNAT1_HUMANGPCR -> GproteingpDB
KPCA_HUMANOPSD_HUMANkinase -> substrateHPRD
ZAGL2_HUMANOPSD_HUMANkinase -> substrateRegPhos
RK_HUMANOPSD_HUMANkinase -> substrateRegPhos
PP2AA_HUMANOPSD_HUMANphosphatase -> substrateHPRD
NRL_HUMANOPSD_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04744Phototransduction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001750photoreceptor outer segmentIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0007603phototransduction, visible lightTASbiological_process
GO:0016918retinal bindingIEAmolecular_function
GO:0060041retina development in camera-type eyeIEAbiological_process
GO:0060342photoreceptor inner segment membraneIDAcellular_component
GO:0030867rough endoplasmic reticulum membraneIEAcellular_component
GO:0050953sensory perception of light stimulusIEAbiological_process
GO:0007601visual perceptionIEAbiological_process
GO:0009585red, far-red light phototransductionIEAbiological_process
GO:0018298protein-chromophore linkageIEAbiological_process
GO:0042622photoreceptor outer segment membraneIDAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005794Golgi apparatusIDAcellular_component
GO:0009583detection of light stimulusIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0016056rhodopsin mediated signaling pathwayIEAbiological_process
GO:0071482cellular response to light stimulusIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007602phototransductionIEAbiological_process
GO:0001750photoreceptor outer segmentIDAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0009416response to light stimulusIEAbiological_process
GO:0001917photoreceptor inner segmentIEAcellular_component
GO:0009881photoreceptor activityIEAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0001917photoreceptor inner segmentIDAcellular_component
GO:0007603phototransduction, visible lightIEAbiological_process