| UniProt/SwissProt ID: | RK_HUMAN |
| Description: | G protein-coupled receptor kinase 1 [Source:HGNC Symbol;Acc:10013] |
| Location: | chr13 q34 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S21 | IAARGsFDGSS | GRK1 | HPRD |
| S491 | DVGAFsTVKGV | GRK1 | HPRD |
| S78 | QQFLQsAEKHL | RGS | PhosphoSitePlus |
| S491 | DVGAFsTVKGV | autocatalysis | RegPhos |
| T492 | VGAFStVKGVA | GRK1 | HPRD |
| T492 | VGAFStVKGVA | autocatalysis | RegPhos |
| T492 | VGAFStVKGVA | RHOK | RegPhos |
| S21 | IAARGsFDGSS | PKA_group | phosphoELM; RegPhos |
| S21 | IAARGsFDGSS | RHOK | RegPhos |
| S21 | IAARGsFDGSS | autocatalysis | RegPhos |
| S21 | IAARGsFDGSS | PhosphoSitePlus | |
| S491 | DVGAFsTVKGV | RHOK | RegPhos |
| Dephosphorylation site |
| RK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000334876 | D274Y | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000334876 | R316C | COSMIC | Gastric Cancer | 21097718 | ENSP00000334876 | A14V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000334876 | P290L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000334876 | K40N | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| RK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RK_HUMAN | RK_HUMAN | kinase -> substrate | RegPhos |
| RK_HUMAN | OPSD_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04144 | Endocytosis |
| hsa04744 | Phototransduction |
| hsa04062 | Chemokine signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050254 | rhodopsin kinase activity | IDA | molecular_function |
| GO:0046777 | protein autophosphorylation | IMP | biological_process |
| GO:0060060 | post-embryonic retina morphogenesis in camera-type | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0009416 | response to light stimulus | IEA | biological_process |
| GO:0007601 | visual perception | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0008594 | photoreceptor cell morphogenesis | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0042327 | positive regulation of phosphorylation | IEA | biological_process |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0008277 | regulation of G-protein coupled receptor protein s | TAS | biological_process |
| GO:0016056 | rhodopsin mediated signaling pathway | TAS | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004703 | G-protein coupled receptor kinase activity | IEA | molecular_function |
| GO:0022400 | regulation of rhodopsin mediated signaling pathway | IDA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0038032 | termination of G-protein coupled receptor signalin | IEA | biological_process |