Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RK_HUMAN
Description:G protein-coupled receptor kinase 1 [Source:HGNC Symbol;Acc:10013]
Location:chr13 q34
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S21IAARGsFDGSSGRK1HPRD
S491DVGAFsTVKGVGRK1HPRD
S78QQFLQsAEKHLRGSPhosphoSitePlus
S491DVGAFsTVKGVautocatalysis RegPhos
T492VGAFStVKGVAGRK1HPRD
T492VGAFStVKGVAautocatalysis RegPhos
T492VGAFStVKGVARHOKRegPhos
S21IAARGsFDGSSPKA_groupphosphoELM; RegPhos
S21IAARGsFDGSSRHOKRegPhos
S21IAARGsFDGSSautocatalysis RegPhos
S21IAARGsFDGSSPhosphoSitePlus
S491DVGAFsTVKGVRHOKRegPhos

Dephosphorylation site
RK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000334876D274YTCGAOvarian Cancer21720365, 18772890
ENSP00000334876R316CCOSMICGastric Cancer21097718
ENSP00000334876A14VCOSMICOvarian Cancer21720365
ENSP00000334876P290LTCGAOvarian Cancer21720365, 18772890
ENSP00000334876K40NCOSMICOvarian Cancer21720365

Differential expressed protein
RK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RK_HUMANRK_HUMANkinase -> substrateRegPhos
RK_HUMANOPSD_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis
hsa04744Phototransduction
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050254rhodopsin kinase activityIDAmolecular_function
GO:0046777protein autophosphorylationIMPbiological_process
GO:0060060post-embryonic retina morphogenesis in camera-typeIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0009416response to light stimulusIEAbiological_process
GO:0007601visual perceptionIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0008594photoreceptor cell morphogenesisIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0042327positive regulation of phosphorylationIEAbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0008277regulation of G-protein coupled receptor protein sTASbiological_process
GO:0016056rhodopsin mediated signaling pathwayTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0004703G-protein coupled receptor kinase activityIEAmolecular_function
GO:0022400regulation of rhodopsin mediated signaling pathwayIDAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process


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