| UniProt/SwissProt ID: | NTR1_HUMAN |
| Description: | neurotensin receptor 1 (high affinity) [Source:HGNC Symbol;Acc:8039] |
| Location: | chr20 q13.33 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T413 | LSSNAtRETLY | PhosphoSitePlus | |
| Dephosphorylation site |
| NTR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000359532 | A270S | COSMIC | Lung Cancer | 20668451 | ENSP00000359532 | T67N | COSMIC | Central Nervous System Neoplasms | 21163964 | ENSP00000359532 | T278M | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| NTR1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NTR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEUT_HUMAN | NTR1_HUMAN | ligand -> receptor | HPMR |
| NTR1_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| NTR1_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04020 | Calcium signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016492 | G-protein coupled neurotensin receptor activity | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0008344 | adult locomotory behavior | IEA | biological_process |
| GO:0005783 | endoplasmic reticulum | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |