Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NRK_HUMAN
Description:Nik related kinase [Source:HGNC Symbol;Acc:25391]
Location:chrX q22.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y858QSSPPySTIDQPhosphoSitePlus
S859SSPPYsTIDQKPhosphoSitePlus
S1031RSHGGsAASEDPhosphoSitePlus
Y1016GKEEAyRGYGSPhosphoSitePlus
Y984DVNNNyYEAPSPhosphoSitePlus
Y885ISPPVyLTNEWPhosphoSitePlus
Y1191NVNPLyVSPACPhosphoSitePlus
S1027HTANRsHGGSAPhosphoSitePlus
S852VTGRRsQSSPPPhosphoSitePlus
Y985VNNNYyEAPSCPhosphoSitePlus
S1362DQSADsEGDYMCNHPhosphoSitePlus
S211NGRRNsFIGTPPkinasePhosphoSitePlus
S855RRSQSsPPYSTPhosphoSitePlus; HPRD
S1359VCIDQsADSEGCNHPhosphoSitePlus
T1242GKADItKLIRRCNHPhosphoSitePlus
Y893NEWVGyNALSEPhosphoSitePlus
S1034GGSAAsEDNAAPhosphoSitePlus

Dephosphorylation site
NRK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000434830Q552LTCGAOvarian Cancer21720365, 18772890
ENSP00000434830D757NBIOMARTLung Cancer21930507, 21930502
ENSP00000434830R901WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000434830I880LHPIColorectal Cancer17344846
ENSP00000434830R1374*BIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000434830S424CHPIbreast ductal carcinoma17344846
ENSP00000434830P789SBIOMARTLung Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000434830Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
NRK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NRK_HUMANCOF1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
NRK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005083small GTPase regulator activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function


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