| UniProt/SwissProt ID: | NRK_HUMAN |
| Description: | Nik related kinase [Source:HGNC Symbol;Acc:25391] |
| Location: | chrX q22.3 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y858 | QSSPPySTIDQ | PhosphoSitePlus | |
| S859 | SSPPYsTIDQK | PhosphoSitePlus | |
| S1031 | RSHGGsAASED | PhosphoSitePlus | |
| Y1016 | GKEEAyRGYGS | PhosphoSitePlus | |
| Y984 | DVNNNyYEAPS | PhosphoSitePlus | |
| Y885 | ISPPVyLTNEW | PhosphoSitePlus | |
| Y1191 | NVNPLyVSPAC | PhosphoSitePlus | |
| S1027 | HTANRsHGGSA | PhosphoSitePlus | |
| S852 | VTGRRsQSSPP | PhosphoSitePlus | |
| Y985 | VNNNYyEAPSC | PhosphoSitePlus | |
| S1362 | DQSADsEGDYM | CNH | PhosphoSitePlus |
| S211 | NGRRNsFIGTP | Pkinase | PhosphoSitePlus |
| S855 | RRSQSsPPYST | PhosphoSitePlus; HPRD | |
| S1359 | VCIDQsADSEG | CNH | PhosphoSitePlus |
| T1242 | GKADItKLIRR | CNH | PhosphoSitePlus |
| Y893 | NEWVGyNALSE | PhosphoSitePlus | |
| S1034 | GGSAAsEDNAA | PhosphoSitePlus | |
| Dephosphorylation site |
| NRK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000434830 | Q552L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000434830 | D757N | BIOMART | Lung Cancer | 21930507, 21930502 | ENSP00000434830 | R901W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000434830 | I880L | HPI | Colorectal Cancer | 17344846 | ENSP00000434830 | R1374* | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000434830 | S424C | HPI | breast ductal carcinoma | 17344846 | ENSP00000434830 | P789S | BIOMART | Lung Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000434830 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | |
| Hyperphosphorylation site |
| NRK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NRK_HUMAN | COF1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| NRK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005083 | small GTPase regulator activity | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |