Phosphorylation

Protein information

UniProt/SwissProt ID:	NICA_HUMAN
Description:	nicastrin [Source:HGNC Symbol;Acc:17091]
Location:	chr1 q23.2
Node attribute:	receptor

Position	PhosphoPeptide	Catalytic kinase	Source
S437	RARNIsGVVLA	Nicastrin	PhosphoSitePlus
T674	ELITLtVGFGI	TM	PhosphoSitePlus
S426	PLPPSsLQRFL	Nicastrin	PhosphoSitePlus
S425	QPLPPsSLQRF	Nicastrin	PhosphoSitePlus
T672	ELELItLTVGF	TM	PhosphoSitePlus

NICA_HUMAN do not have dephosphorylation site.

NICA_HUMAN do not have mutation site.

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000294785	Hepatocellular Carcinoma	Normal vs. Cancer	cell line	Down	0.31	19120023

NICA_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
PSN1_HUMAN	NICA_HUMAN	ligand -> receptor	HPMR

KEGG Pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0050435	beta-amyloid metabolic process	IEA	biological_process
GO:0005886	plasma membrane	IEA	cellular_component
GO:0008233	peptidase activity	IEA	molecular_function
GO:0048011	nerve growth factor receptor signaling pathway	TAS	biological_process
GO:0031293	membrane protein intracellular domain proteolysis	TAS	biological_process
GO:0016021	integral to membrane	IEA	cellular_component
GO:0006508	proteolysis	NAS	biological_process
GO:0007219	Notch signaling pathway	TAS	biological_process
GO:0005887	integral to plasma membrane	ISS	cellular_component
GO:0043085	positive regulation of catalytic activity	ISS	biological_process
GO:0002262	myeloid cell homeostasis	IEA	biological_process
GO:0042098	T cell proliferation	IEA	biological_process
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0042987	amyloid precursor protein catabolic process	TAS	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0006509	membrane protein ectodomain proteolysis	ISS	biological_process
GO:0042470	melanosome	IEA	cellular_component
GO:0050673	epithelial cell proliferation	IEA	biological_process
GO:0005765	lysosomal membrane	IEA	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0006915	apoptotic process	TAS	biological_process
GO:0007220	Notch receptor processing	TAS	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0004175	endopeptidase activity	IEA	molecular_function
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0016485	protein processing	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network