Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NDRG1_HUMAN
Description:N-myc downstream regulated 1 [Source:HGNC Symbol;Acc:7679]
Location:chr8 q24.22
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T340TSLDGtRSRSHPhosphoSitePlus
T350HTSEGtRSRSHPhosphoSitePlus
S326TRLMRsRTASGPhosphoSitePlus; HPRD; phosphoELM
T335SGSSVtSLDGTPhosphoSitePlus; HPRD; phosphoELM
S2____MsREMQDPhosphoSitePlus
S344GTRSRsHTSEGPhosphoSitePlus
S319YMPSAsMTRLMPhosphoSitePlus; HPRD; phosphoELM
S330RSRTAsGSSVTSGK_groupphosphoELM
S389SAGPKsMEVSCPhosphoSitePlus
S347SRSHTsEGTRSPhosphoSitePlus
S357SRSHTsEGTRSPhosphoSitePlus
S333TASGSsVTSLDPhosphoSitePlus; HPRD; phosphoELM
S342LDGTRsRSHTSPhosphoSitePlus; phosphoELM
T375AHLDItPNSGAPhosphoSitePlus; HPRD; phosphoELM
T328LMRSRtASGSSPhosphoSitePlus; HPRD; phosphoELM
S352SEGTRsRSHTSPhosphoSitePlus; phosphoELM
T366RSRSHtSEGAHPRKACAHPRD
S332RTASGsSVTSLPhosphoSitePlus; HPRD; phosphoELM
T346RSRSHtSEGTRPhosphoSitePlus
S393KSMEVsC____PhosphoSitePlus
S384GAAGNsAGPKSPhosphoSitePlus; HPRD; phosphoELM
G331SRTASgSSVTSHPRD
S362SEGTRsRSHTSPhosphoSitePlus; HPRD; phosphoELM
T328LMRSRtASGSSSGK_groupphosphoELM
T366RSRSHtSEGAHPhosphoSitePlus; phosphoELM
S378DITPNsGAAGNPhosphoSitePlus; HPRD
Y307AEAFKyFVQGMNdrPhosphoSitePlus
S354GTRSRsHTSEGPhosphoSitePlus
T356RSRSHtSEGTRSGK_groupphosphoELM
S330RSRTAsGSSVTPRKACAHPRD
S336GSSVTsLDGTRPhosphoSitePlus; HPRD; phosphoELM
S330RSRTAsGSSVTPhosphoSitePlus; HPRD; phosphoELM
S367SRSHTsEGAHLPhosphoSitePlus; HPRD; phosphoELM
T360HTSEGtRSRSHPhosphoSitePlus
S364GTRSRsHTSEGPhosphoSitePlus; HPRD; phosphoELM
T346RSRSHtSEGTRSGK_groupphosphoELM
T356RSRSHtSEGTRPhosphoSitePlus

Dephosphorylation site
NDRG1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000319977V17LCOSMICOvarian Cancer21720365
ENSP00000404854V17LCOSMICOvarian Cancer21720365
ENSP00000319977Q6RCOSMICOvarian Cancer21720365
ENSP00000404854V269MCOSMICOvarian Cancer21720365
ENSP00000404854Q6RCOSMICOvarian Cancer21720365
ENSP00000319977V269MCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000404854Oral CancerNormal vs. CancertissueUp3.819297561
ENSP00000404854Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.2919120023
ENSP00000404854Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineDown0.4818253933
ENSP00000404854Breast CancerMetastasiscell lineUp2.0-5.519321434
ENSP00000404854Breast CancerMetastasiscell lineUp20155427
ENSP00000404854Renal CancerNormal vs. CancertissueUp19164279

Hyperphosphorylation site
NDRG1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANNDRG1_HUMANkinase -> substrateHPRD
P53_HUMANNDRG1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
NDRG1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0090232positive regulation of spindle checkpointIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0008017microtubule bindingIDAmolecular_function
GO:0043015gamma-tubulin bindingIDAmolecular_function
GO:0005813centrosomeIDAcellular_component
GO:0055038recycling endosome membraneIDAcellular_component
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0030330DNA damage response, signal transduction by p53 clIEPbiological_process
GO:0005913cell-cell adherens junctionIDAcellular_component
GO:0032287peripheral nervous system myelin maintenanceIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0010038response to metal ionTASbiological_process
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0045296cadherin bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005829cytosolIEAcellular_component
GO:0071456cellular response to hypoxiaIEPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005874microtubuleIDAcellular_component
GO:0017137Rab GTPase bindingIDAmolecular_function
GO:0045576mast cell activationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component


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