| UniProt/SwissProt ID: | NDC80_HUMAN |
| Description: | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:16909] |
| Location: | chr18 p11.32 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T502 | KRSVRtLKEEV | Prominin; SlyX | PhosphoSitePlus |
| S66 | TSGHGsRNSQL | HPRD | |
| S62 | FGKRTsGHGSR | Ndc80_HEC | PhosphoSitePlus |
| Y458 | YRAQVyVPLKE | PhosphoSitePlus | |
| T49 | SINKPtSERKV | Ndc80_HEC | PhosphoSitePlus |
| S69 | HGSRNsQLGIF | HPRD | |
| S62 | FGKRTsGHGSR | HPRD; phosphoELM; RegPhos | |
| S55 | SERKVsLFGKR | Ndc80_HEC | PhosphoSitePlus |
| S165 | YPFALsKSSMY | Ndc80_HEC; Cluap1 | PhosphoSitePlus |
| Y361 | IDNQKySVADI | Reo_sigmaC; SlyX | PhosphoSitePlus |
| S55 | SERKVsLFGKR | HPRD; phosphoELM; RegPhos | |
| S77 | GIFSSsEKIKD | Ndc80_HEC | PhosphoSitePlus |
| S69 | HGSRNsQLGIF | Ndc80_HEC | PhosphoSitePlus |
| S76 | LGIFSsSEKIK | HPRD; phosphoELM; RegPhos | |
| T34 | LYTPQtKEKPT | HPRD | |
| S595 | ATHVGsVEKHL | Prominin; DUF1664 | PhosphoSitePlus |
| T591 | LEMVAtHVGSV | Prominin; DUF1664 | PhosphoSitePlus |
| S5 | _MKRSsVSSGG | PhosphoSitePlus | |
| S165 | YPFALsKSSMY | NEK2 | HPRD; phosphoELM; RegPhos |
| S76 | LGIFSsSEKIK | Ndc80_HEC | PhosphoSitePlus |
| Y30 | NKQGLyTPQTK | PhosphoSitePlus | |
| S50 | INKPTsERKVS | HPRD | |
| S44 | TFGKLsINKPT | PhosphoSitePlus; HPRD | |
| S15 | GAGRLsMQELR | PhosphoSitePlus | |
| T31 | KQGLYtPQTKE | PhosphoSitePlus; HPRD | |
| S77 | GIFSSsEKIKD | HPRD; phosphoELM; RegPhos | |
| Dephosphorylation site |
| NDC80_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000261597 | D628fs*9 | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| NDC80_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NDC80_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEK2_HUMAN | NDC80_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | NDC80_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| NDC80_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000776 | kinetochore | IDA | cellular_component |
| GO:0008608 | attachment of spindle microtubules to kinetochore | IMP | biological_process |
| GO:0007052 | mitotic spindle organization | IMP | biological_process |
| GO:0000775 | chromosome, centromeric region | TAS | cellular_component |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0007059 | chromosome segregation | IMP | biological_process |
| GO:0000777 | condensed chromosome kinetochore | IDA | cellular_component |
| GO:0000942 | condensed nuclear chromosome outer kinetochore | IDA | cellular_component |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0048015 | phosphatidylinositol-mediated signaling | NAS | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0007049 | cell cycle | NAS | biological_process |
| GO:0007067 | mitosis | TAS | biological_process |
| GO:0000132 | establishment of mitotic spindle orientation | IMP | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0000087 | M phase of mitotic cell cycle | TAS | biological_process |
| GO:0000070 | mitotic sister chromatid segregation | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0031262 | Ndc80 complex | IDA | cellular_component |
| GO:0000236 | mitotic prometaphase | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016192 | vesicle-mediated transport | IEA | biological_process |
| GO:0007051 | spindle organization | NAS | biological_process |