| UniProt/SwissProt ID: | NCOA4_HUMAN |
| Description: | nuclear receptor coactivator 4 [Source:HGNC Symbol;Acc:7671] |
| Location: | chr10 q11.23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S194 | EQKSAsGIVAV | PhosphoSitePlus | |
| S237 | QTLENsQTSSR | PhosphoSitePlus | |
| S240 | ENSQTsSRACN | PhosphoSitePlus | |
| S456 | EKHKDsLNMWL | PhosphoSitePlus; HPRD; phosphoELM | |
| S241 | NSQTSsRACNF | PhosphoSitePlus | |
| S212 | GSKPAsGYQAP | PhosphoSitePlus | |
| S334 | KLLFQsYNVND | PhosphoSitePlus | |
| S57 | IHSCIsRHLEC | PhosphoSitePlus | |
| S192 | MPEQKsASGIV | HPRD | |
| Dephosphorylation site |
| NCOA4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363200 | Y71* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000390713 | Y71* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000344552 | S267P | COSMIC | Skin Cancer | 21984974 | ENSP00000344552 | Y71* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000390713 | S267P | COSMIC | Skin Cancer | 21984974 | ENSP00000363200 | S267P | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| NCOA4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NCOA4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ST17A_HUMAN | NCOA4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | NCOA4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | NCOA4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | NCOA4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NCOA4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | NAS | molecular_function |
| GO:0030521 | androgen receptor signaling pathway | NAS | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | NAS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0050681 | androgen receptor binding | NAS | molecular_function |
| GO:0008584 | male gonad development | TAS | biological_process |
| GO:0005634 | nucleus | TAS | cellular_component |