Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NCK1_HUMAN
Description:NCK adaptor protein 1 [Source:HGNC Symbol;Acc:7664]
Location:chr3 q22.3
Node attribute:kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S61VERKNsARKASPhosphoSitePlus
T161PSNYVtEEGDSHPRD; phosphoELM
S96SPADDsFVDPGPhosphoSitePlus; HPRD; phosphoELM
S166TEEGDsPLGDHPhosphoSitePlus; HPRD; phosphoELM
S66SARKAsIVKNLPhosphoSitePlus
S262SGLEPsPPQCDHPRD
Y112LNMPAyVKFNYSH3_1PhosphoSitePlus
Y105PGERLyDLNMPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S89PSVPDsASPADPhosphoSitePlus; HPRD; phosphoELM
Y268PPQCDyIRPSLPhosphoSitePlus; HPRD; phosphoELM
Y246LVPKNyVTVMQHPRD
S85VKRKPsVPDSAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T74KNLKDtLGIGKPhosphoSitePlus; HPRD; SysPTM
S313RDSESsPNDFSHPRD
Y13VAKFDyVAQQESH3_1PhosphoSitePlus
S312IRDSEsSPNDFHPRD
S347GQRKFsTMEELSH2PhosphoSitePlus
Y339LKETVyCIGQRSH2PhosphoSitePlus
S91VPDSAsPADDSPhosphoSitePlus; HPRD; phosphoELM; SysPTM

Dephosphorylation site
NCK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000288986R63WCOSMICPancreatic Cancer
ENSP00000288986E336QCOSMICHead and Neck Cancer21798893
ENSP00000417273E336QCOSMICHead and Neck Cancer21798893
ENSP00000417273R63WCOSMICPancreatic Cancer

Differential expressed protein
NCK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y105VDPGERLyDLNMPAYcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
NCK1_HUMANPLCG1_HUMANkinase -> substrateKEGG
NCK1_HUMANABL1_HUMANotherKEGG
NCK1_HUMANMP2K7_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04660T cell receptor signaling pathway
hsa04012ErbB signaling pathway
hsa05130Pathogenic Escherichia coli infection
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007015actin filament organizationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0008093cytoskeletal adaptor activityNASmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0030159receptor signaling complex scaffold activityNASmolecular_function
GO:0030838positive regulation of actin filament polymerizatiIEAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0005737cytoplasmNAScellular_component
GO:0016477cell migrationIEAbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006417regulation of translationIEAbiological_process
GO:0030838positive regulation of actin filament polymerizatiIMPbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0007172signal complex assemblyNASbiological_process
GO:0030032lamellipodium assemblyIEAbiological_process
GO:0042110T cell activationIMPbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0042102positive regulation of T cell proliferationIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0012506vesicle membraneIEAcellular_component
GO:0005634nucleusIEAcellular_component


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