Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NCF4_HUMAN
Description:neutrophil cytosolic factor 4, 40kDa [Source:HGNC Symbol;Acc:7662]
Location:chr22 q12.3
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T154RLRPRtRKVKSPKC_groupphosphoELM; RegPhos
S315ARGLPsQKRLFPKCa(PKC alphaRegPhos
T154RLRPRtRKVKSPKCa(PKC alphaRegPhos
Y243NWLRCyYYEDTPB1PhosphoSitePlus
T154RLRPRtRKVKSPRKCDHPRD
S315ARGLPsQKRLFPKC_alphaphosphoELM
Y245LRCYYyEDTISPB1PhosphoSitePlus
T154RLRPRtRKVKSPhosphoSitePlus; RegPhos
T154RLRPRtRKVKSPKCdRegPhos
S11QLRAEsDFEQLPhosphoSitePlus
S315ARGLPsQKRLFPB1PhosphoSitePlus
S315ARGLPsQKRLFRegPhos
S23DDVAIsANIADPhosphoSitePlus
T154RLRPRtRKVKSPKC_alphaphosphoELM
S161KVKSVsPQGNSPhosphoSitePlus

Dephosphorylation site
NCF4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000248899A102TTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000248899R105QCOSMICSkin Cancer21984974

Differential expressed protein
NCF4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NCF4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANNCF4_HUMANkinase -> substrateHPRD
ZAGL2_HUMANNCF4_HUMANkinase -> substrateRegPhos
KPCA_HUMANNCF4_HUMANkinase -> substrateRobert H Newman (2013)
SPI1_HUMANNCF4_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05140Leishmaniasis
hsa04670Leukocyte transendothelial migration
hsa04380Osteoclast differentiation
hsa04145Phagosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIDAcellular_component
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0051701interaction with hostTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0032010phagolysosomeTAScellular_component
GO:0055114oxidation-reduction processTASbiological_process
GO:0006955immune responseTASbiological_process
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0046983protein dimerization activityTASmolecular_function
GO:0005829cytosolIDAcellular_component
GO:0090382phagosome maturationTASbiological_process
GO:0043020NADPH oxidase complexIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0002479antigen processing and presentation of exogenous pTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007154cell communicationIEAbiological_process
GO:0035091phosphatidylinositol bindingIEAmolecular_function


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