Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MYLK2_HUMAN
Description:myosin light chain kinase 2 [Source:HGNC Symbol;Acc:16243]
Location:chr20 q11.21
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S588KKISSsGALMAPhosphoSitePlus
S143AARRGsPAFLHPhosphoSitePlus
S587FKKISsSGALMPhosphoSitePlus
S586RFKKIsSSGALPhosphoSitePlus
Y563ILLKKyLMKRRPhosphoSitePlus

Dephosphorylation site
MYLK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365162A117VGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000365152H377QTCGAOvarian Cancer21720365, 18772890
ENSP00000365162H377QTCGAOvarian Cancer21720365, 18772890
ENSP00000365152P111TBIOMARTBreast Cancer21930507, 21930502
ENSP00000365152A117VGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000365152S72NTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000365162P111TBIOMARTBreast Cancer21930507, 21930502
ENSP00000365162S72NTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
MYLK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MYLK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MYLK2_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
MYLK2_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
MYLK2_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
MYLK2_HUMANZN396_HUMANkinase -> substrateRobert H Newman (2013)
MYLK2_HUMANM4K5_HUMANkinase -> substrateRobert H Newman (2013)
MYLK2_HUMAN2AAB_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MYLK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032971regulation of muscle filament slidingIDAbiological_process
GO:0055007cardiac muscle cell differentiationIEAbiological_process
GO:0004683calmodulin-dependent protein kinase activityISSmolecular_function
GO:0055008cardiac muscle tissue morphogenesisIMPbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0060048cardiac muscle contractionICbiological_process
GO:0018107peptidyl-threonine phosphorylationIDAbiological_process
GO:0004687myosin light chain kinase activityISSmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0035914skeletal muscle cell differentiationIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005516calmodulin bindingISSmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0035914skeletal muscle cell differentiationIEAbiological_process
GO:0006941striated muscle contractionIDAbiological_process
GO:0014816satellite cell differentiationIEAbiological_process
GO:0007274neuromuscular synaptic transmissionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0030017sarcomereICcellular_component
GO:0005515protein bindingIPImolecular_function


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