Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MYCN_HUMAN
Description:v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) [Source:HGNC Symbol;Acc:7559]
Location:chr2 p24.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T58FELLPtPPLSPMyc_NPhosphoSitePlus
T58FELLPtPPLSPHPRD; phosphoELM; RegPhos
S261GEDTLsDSDDECSNK2A1HPRD
S261GEDTLsDSDDECSNK2A2HPRD
S261GEDTLsDSDDEMyc_N; LRS4; BSP_II; CenpPhosphoSitePlus
S263DTLSDsDDEDDCSNK2A2HPRD
S263DTLSDsDDEDDCSNK2A1HPRD
S261GEDTLsDSDDECK2_alphaphosphoELM
S62PTPPLsPSRGFHPRD; phosphoELM; RegPhos
S261GEDTLsDSDDECK2a1-rsRegPhos
S62PTPPLsPSRGFMyc_NPhosphoSitePlus
S261GEDTLsDSDDECK2_groupphosphoELM; RegPhos
S263DTLSDsDDEDDCK2a1-rsRegPhos
S263DTLSDsDDEDDCK2a1(CK2 alphaRegPhos
S5STMPphosphoELM
S263DTLSDsDDEDDMyc_N; LRS4; BSP_II; CenpPhosphoSitePlus
S156GAGAAsPAGRGMyc_NPhosphoSitePlus
S263DTLSDsDDEDDCK2_groupphosphoELM; RegPhos
S261GEDTLsDSDDECK2a1RegPhos
S261GEDTLsDSDDECK2a2RegPhos
S7MPGMphosphoELM
S64PPLSPsRGFAEMyc_NPhosphoSitePlus
T6TMPGphosphoELM
S3STSTphosphoELM
S263DTLSDsDDEDDCK2a2RegPhos
S263DTLSDsDDEDDCK2a1RegPhos
S261GEDTLsDSDDECK2a1(CK2 alphaRegPhos
T8SCSTStMPGMIphosphoELM
S263DTLSDsDDEDDCK2_alphaphosphoELM

Dephosphorylation site
MYCN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000281043P358LTCGAOvarian Cancer21720365, 18772890
ENSP00000281043P74LCOSMICMelanoma
ENSP00000281043P358LCOSMICOvarian Cancer21720365
ENSP00000281043L402FDing2008, COSMICLung Cancer18948947
ENSP00000281043P345TBIOMARTBreast Cancer21930507, 21930502
ENSP00000281043P44LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000281043P44LTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
MYCN_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MYCN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK22_HUMANMYCN_HUMANkinase -> substrateHPRD
CSK21_HUMANMYCN_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANMYCN_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000785chromatinTAScellular_component
GO:2000378negative regulation of reactive oxygen species metIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0042733embryonic digit morphogenesisIEAbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0048712negative regulation of astrocyte differentiationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0010942positive regulation of cell deathIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0001502cartilage condensationIEAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0048704embryonic skeletal system morphogenesisIEAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0005515protein bindingIPImolecular_function