| UniProt/SwissProt ID: | MTG8_HUMAN |
| Description: | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) [Source:HGNC Symbol;Acc:1535] |
| Location: | chr8 q21.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T568 | STTPGtPSTIE | HPRD | |
| T595 | STTPGtPSTIE | PhosphoSitePlus; HPRD | |
| S390 | HSRQQsPVNPD | HPRD | |
| T592 | TPRSTtPGTPS | PhosphoSitePlus; HPRD | |
| T564 | ATPRStTPGTP | HPRD | |
| S563 | AATPRsTTPGT | HPRD | |
| T52 | TQSRLtPPTMP | PhosphoSitePlus | |
| S590 | AATPRsTTPGT | PhosphoSitePlus; HPRD | |
| T55 | RLTPPtMPPPP | PhosphoSitePlus | |
| S417 | HSRQQsPVNPD | PhosphoSitePlus; HPRD | |
| T47 | PVDVKtQSRLT | PhosphoSitePlus | |
| T591 | ATPRStTPGTP | PhosphoSitePlus; HPRD | |
| S41 | STMPDsPVDVK | PhosphoSitePlus | |
| T565 | TPRSTtPGTPS | HPRD | |
| Y315 | HYRDSyRHPSH | PhosphoSitePlus | |
| Dephosphorylation site |
| MTG8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265814 | R395W | BIOMART, HPI | Colorectal Cancer | 21930507, 21930502, 16959974 | ENSP00000265814 | D303Y | COSMIC | Lung Cancer | 20668451 | ENSP00000265814 | A501S | COSMIC | Lung Cancer | 20668451 | ENSP00000265814 | R386W | BIOMART, HPI | Colorectal Cancer | 21930507, 21930502, 16959974 | ENSP00000265814 | G240R | COSMIC | Lung Cancer | 20668451 | ENSP00000265814 | S527N | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000265814 | S124G | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000265814 | R386W | Sjoblom2006 | Intestines Cancer | 16959974, 21930507, 21930502 | ENSP00000265814 | G439E | COSMIC | Lung Cancer | 20668451 | ENSP00000265814 | S104G | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000265814 | E499K | COSMIC | Lung Cancer | 20668451 | ENSP00000265814 | P267Q | COSMIC | Lung Cancer | 20668451 | ENSP00000265814 | A471V | BIOMART, HPI | Colorectal Cancer | 21930507, 21930502, 16959974 | ENSP00000265814 | R520H | COSMIC | Breast Cancer | 20668451 | ENSP00000265814 | E256D | COSMIC | Breast Cancer | 20668451 | ENSP00000265814 | R395W | Sjoblom2006 | Intestines Cancer | 16959974, 21930507, 21930502 | ENSP00000265814 | R10K | COSMIC | Central Nervous System Neoplasms | ENSP00000265814 | A471V | Sjoblom2006 | Intestines Cancer | 16959974, 21930507, 21930502 |
| Differential expressed protein |
| MTG8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MTG8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TRIB3_HUMAN | MTG8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | MTG8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | MTG8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | MTG8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MTG8_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0045444 | fat cell differentiation | IEA | biological_process |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0051101 | regulation of DNA binding | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0006091 | generation of precursor metabolites and energy | TAS | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0016363 | nuclear matrix | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |