Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MTG8_HUMAN
Description:runt-related transcription factor 1; translocated to, 1 (cyclin D-related) [Source:HGNC Symbol;Acc:1535]
Location:chr8 q21.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T568STTPGtPSTIEHPRD
T595STTPGtPSTIEPhosphoSitePlus; HPRD
S390HSRQQsPVNPDHPRD
T592TPRSTtPGTPSPhosphoSitePlus; HPRD
T564ATPRStTPGTPHPRD
S563AATPRsTTPGTHPRD
T52TQSRLtPPTMPPhosphoSitePlus
S590AATPRsTTPGTPhosphoSitePlus; HPRD
T55RLTPPtMPPPPPhosphoSitePlus
S417HSRQQsPVNPDPhosphoSitePlus; HPRD
T47PVDVKtQSRLTPhosphoSitePlus
T591ATPRStTPGTPPhosphoSitePlus; HPRD
S41STMPDsPVDVKPhosphoSitePlus
T565TPRSTtPGTPSHPRD
Y315HYRDSyRHPSHPhosphoSitePlus

Dephosphorylation site
MTG8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265814R395WBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000265814D303YCOSMICLung Cancer20668451
ENSP00000265814A501SCOSMICLung Cancer20668451
ENSP00000265814R386WBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000265814G240RCOSMICLung Cancer20668451
ENSP00000265814S527NCOSMICHead and Neck Cancer21984974
ENSP00000265814S124GBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000265814R386WSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000265814G439ECOSMICLung Cancer20668451
ENSP00000265814S104GBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000265814E499KCOSMICLung Cancer20668451
ENSP00000265814P267QCOSMICLung Cancer20668451
ENSP00000265814A471VBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000265814R520HCOSMICBreast Cancer20668451
ENSP00000265814E256DCOSMICBreast Cancer20668451
ENSP00000265814R395WSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000265814R10KCOSMICCentral Nervous System Neoplasms
ENSP00000265814A471VSjoblom2006Intestines Cancer16959974, 21930507, 21930502

Differential expressed protein
MTG8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MTG8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TRIB3_HUMANMTG8_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANMTG8_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANMTG8_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANMTG8_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MTG8_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045444fat cell differentiationIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0051101regulation of DNA bindingIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0006091generation of precursor metabolites and energyTASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0016363nuclear matrixIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process


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