| UniProt/SwissProt ID: | MTF1_HUMAN |
| Description: | metal-regulatory transcription factor 1 [Source:HGNC Symbol;Acc:7428] |
| Location: | chr1 p34.3 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y151 | GCPRTySTAGN | zf-C2H2 | PhosphoSitePlus |
| Y215 | AFNTLyRLKAH | zf-C2H2 | PhosphoSitePlus |
| T252 | RKHIRtHTGEK | zf-C2H2 | PhosphoSitePlus |
| S39 | GLVPSsSGTVY | PhosphoSitePlus | |
| Y140 | KEVKRyQCTFE | HPRD; phosphoELM | |
| S620 | QQIGLsVPVII | PhosphoSitePlus | |
| S305 | FSTQYsLKSHM | zf-C2H2 | PhosphoSitePlus |
| T254 | HIRTHtGEKPF | PhosphoSitePlus | |
| Y140 | KEVKRyQCTFE | zf-C2H2 | PhosphoSitePlus |
| Dephosphorylation site |
| MTF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362127 | G255R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362127 | Q161H | COSMIC | Pancreatic Cancer |
| Differential expressed protein |
| MTF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MTF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MTF1_HUMAN | MT2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| MTF1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0035035 | histone acetyltransferase binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0046686 | response to cadmium ion | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0010038 | response to metal ion | TAS | biological_process |
| GO:0006979 | response to oxidative stress | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0001047 | core promoter binding | IDA | molecular_function |
| GO:0000979 | RNA polymerase II core promoter sequence-specific | IEA | molecular_function |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |