| UniProt/SwissProt ID: | MK67I_HUMAN |
| Description: | MKI67 (FHA domain) interacting nucleolar phosphoprotein [Source:HGNC Symbol;Acc:17838] |
| Location: | chr2 q14.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S291 | KRRRSsNQ___ | PhosphoSitePlus | |
| S230 | EKTVDsQGPTP | hNIFK_binding | PhosphoSitePlus |
| S204 | TNRQTsTKGQV | PhosphoSitePlus | |
| Y88 | GNSKGyAFVEF | RRM_1 | PhosphoSitePlus |
| T156 | RNRTLtQKLRM | PhosphoSitePlus | |
| T234 | DSQGPtPVCTP | HPRD; phosphoELM; RegPhos | |
| T199 | ESISKtNRQTS | PhosphoSitePlus | |
| T240 | PVCTPtFLERR | HPRD; phosphoELM; RegPhos | |
| S230 | EKTVDsQGPTP | GSK3B(GSK3 beta | RegPhos |
| Y183 | KKGIDyDFPSL | PhosphoSitePlus | |
| S230 | EKTVDsQGPTP | GSK3A(GSK3 alpha | RegPhos |
| T227 | DTPEKtVDSQG | HPRD; phosphoELM | |
| T234 | DSQGPtPVCTP | GSK3A(GSK3 alpha | RegPhos |
| T277 | EEIQEtQTPTH | PhosphoSitePlus | |
| T238 | PTPVCtPTFLE | HPRD; phosphoELM; RegPhos | |
| S290 | KKRRRsSNQ__ | PhosphoSitePlus | |
| S230 | EKTVDsQGPTP | GSK-3_beta | phosphoELM |
| S247 | LERRKsQVAEL | hNIFK_binding | PhosphoSitePlus; SysPTM |
| T238 | PTPVCtPTFLE | hNIFK_binding | PhosphoSitePlus |
| T234 | DSQGPtPVCTP | hNIFK_binding | PhosphoSitePlus |
| T220 | KKVSGtLDTPE | PhosphoSitePlus; HPRD; phosphoELM | |
| T234 | DSQGPtPVCTP | GSK3B(GSK3 beta | RegPhos |
| S218 | KKKKVsGTLDT | PhosphoSitePlus; HPRD; phosphoELM | |
| T154 | YNRNRtLTQKL | PhosphoSitePlus | |
| T223 | SGTLDtPEKTV | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S230 | EKTVDsQGPTP | GSK-3_alpha | phosphoELM |
| T234 | DSQGPtPVCTP | GSK-3_beta | phosphoELM |
| S247 | LERRKsQVAEL | HPRD; phosphoELM; RegPhos; SysPTM | |
| T234 | DSQGPtPVCTP | GSK-3_alpha | phosphoELM |
| T240 | PVCTPtFLERR | hNIFK_binding | PhosphoSitePlus |
| S230 | EKTVDsQGPTP | HPRD; phosphoELM; RegPhos | |
| T279 | IQETQtPTHSR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T227 | DTPEKtVDSQG | hNIFK_binding | PhosphoSitePlus |
| Dephosphorylation site |
| MK67I_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000285814 | R153Q | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| MK67I_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MK67I_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GSK3B_HUMAN | MK67I_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | MK67I_HUMAN | kinase -> substrate | RegPhos |
| GSK3A_HUMAN | MK67I_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MK67I_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0010923 | negative regulation of phosphatase activity | IDA | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0009303 | rRNA transcription | NAS | biological_process |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006461 | protein complex assembly | NAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005654 | nucleoplasm | IDA | cellular_component |
| GO:0000794 | condensed nuclear chromosome | IDA | cellular_component |
| GO:0016072 | rRNA metabolic process | NAS | biological_process |