Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MGRN1_HUMAN
Description:mahogunin ring finger 1, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:20254]
Location:chr16 p13.3
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T454KAPDStLRSPSHPRD; phosphoELM
S459TLRSPsSPIHEHPRD; phosphoELM
S524VLQDSsPEHCGHPRD; phosphoELM

Dephosphorylation site
MGRN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262370S233FCOSMICOvarian Cancer21720365
ENSP00000262370E494KCOSMICHead and Neck Cancer21798893
ENSP00000262370L60RCOSMICOvarian Cancer21720365
ENSP00000262370E467KCOSMICHead and Neck Cancer21798893
ENSP00000262370P478SCOSMICMelanoma21499247

Differential expressed protein
MGRN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MGRN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ASIP_HUMANMGRN1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04120Ubiquitin mediated proteolysis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0045744negative regulation of G-protein coupled receptor IDAbiological_process
GO:0006513protein monoubiquitinationIMPbiological_process
GO:0008333endosome to lysosome transportIMPbiological_process
GO:0000209protein polyubiquitinationIEAbiological_process
GO:0043951negative regulation of cAMP-mediated signalingIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0005769early endosomeIDAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function


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