| UniProt/SwissProt ID: | ASIP_HUMAN |
| Description: | agouti signaling protein [Source:HGNC Symbol;Acc:745] |
| Location: | chr20 q11.22 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S35 | LRDDRsLRSNS | Agouti | PhosphoSitePlus |
| Dephosphorylation site |
| ASIP_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000454804 | *133K | COSMIC | Melanoma | 21499247 | ENSP00000364092 | *133K | COSMIC | Melanoma | 21499247 | ENSP00000364092 | D109N | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| ASIP_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ASIP_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ASIP_HUMAN | MGRN1_HUMAN | ligand -> receptor | HPMR |
| ASIP_HUMAN | ATRN_HUMAN | ligand -> receptor | HPMR |
| ASIP_HUMAN | MSHR_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04916 | Melanogenesis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009755 | hormone-mediated signaling pathway | IEA | biological_process |
| GO:0005615 | extracellular space | TAS | cellular_component |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0006091 | generation of precursor metabolites and energy | IEA | biological_process |
| GO:0031781 | type 3 melanocortin receptor binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0031779 | melanocortin receptor binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0071514 | genetic imprinting | IEA | biological_process |
| GO:0043473 | pigmentation | IEA | biological_process |
| GO:0040030 | regulation of molecular function, epigenetic | IEA | biological_process |
| GO:0008343 | adult feeding behavior | IEA | biological_process |
| GO:0032438 | melanosome organization | IEA | biological_process |
| GO:0031782 | type 4 melanocortin receptor binding | IEA | molecular_function |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0032402 | melanosome transport | IEA | biological_process |
| GO:0042438 | melanin biosynthetic process | IEA | biological_process |
| GO:0005102 | receptor binding | TAS | molecular_function |