| UniProt/SwissProt ID: | MGRN1_HUMAN |
| Description: | mahogunin ring finger 1, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:20254] |
| Location: | chr16 p13.3 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T454 | KAPDStLRSPS | HPRD; phosphoELM | |
| S459 | TLRSPsSPIHE | HPRD; phosphoELM | |
| S524 | VLQDSsPEHCG | HPRD; phosphoELM | |
| Dephosphorylation site |
| MGRN1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000262370 | S233F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000262370 | E494K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000262370 | L60R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000262370 | E467K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000262370 | P478S | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| MGRN1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MGRN1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ASIP_HUMAN | MGRN1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04120 | Ubiquitin mediated proteolysis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0045744 | negative regulation of G-protein coupled receptor | IDA | biological_process |
| GO:0006513 | protein monoubiquitination | IMP | biological_process |
| GO:0008333 | endosome to lysosome transport | IMP | biological_process |
| GO:0000209 | protein polyubiquitination | IEA | biological_process |
| GO:0043951 | negative regulation of cAMP-mediated signaling | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0004842 | ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005769 | early endosome | IDA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |