| UniProt/SwissProt ID: | MFN1_HUMAN |
| Description: | mitofusin 1 [Source:HGNC Symbol;Acc:18262] |
| Location: | chr3 q26.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T687 | QQVDItQKQLE | Fzo_mitofusin | PhosphoSitePlus |
| Dephosphorylation site |
| MFN1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263969 | D415H | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000263969 | E209K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000420617 | E209K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000263969 | D415H | HPI | Colorectal Cancer | 16959974 | ENSP00000420617 | F35Y | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000420617 | D415H | HPI | Colorectal Cancer | 16959974 | ENSP00000263969 | L484P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000263969 | F35Y | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000263969 | F35Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000263969 | E209K | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| MFN1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MFN1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEK6_HUMAN | MFN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MFN1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005741 | mitochondrial outer membrane | IEA | cellular_component |
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0008053 | mitochondrial fusion | IEA | biological_process |
| GO:0006184 | GTP catabolic process | IEA | biological_process |