| UniProt/SwissProt ID: | MELK_HUMAN |
| Description: | maternal embryonic leucine zipper kinase [Source:HGNC Symbol;Acc:16870] |
| Location: | chr9 p13.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T167 | DYHLQtCCGSL | Pkinase | PhosphoSitePlus |
| T494 | TDKLMtGVISP | PhosphoSitePlus; HPRD; SysPTM | |
| S343 | SCGQAsATPFT | PhosphoSitePlus | |
| S431 | VYTPKsAVKNE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S335 | VRLRLsSFSCG | PhosphoSitePlus; HPRD | |
| S498 | MTGVIsPERRC | PhosphoSitePlus; HPRD; SysPTM | |
| T446 | FPEPKtPVNKN | PhosphoSitePlus; HPRD; SysPTM | |
| S468 | RYTTPsKARNQ | PhosphoSitePlus | |
| T460 | REILTtPNRYT | PhosphoSitePlus; HPRD; SysPTM | |
| S407 | GVESKsLTPAL | PhosphoSitePlus | |
| S253 | PKKRIsMKNLL | Pkinase | PhosphoSitePlus |
| S486 | KIPVNsTGTDK | HPRD | |
| T539 | LDKVItVLTRS | PhosphoSitePlus | |
| Y427 | NKENVyTPKSA | PhosphoSitePlus | |
| Y88 | FMVLEyCPGGE | Pkinase | PhosphoSitePlus |
| T415 | PALCRtPANKL | PhosphoSitePlus | |
| T167 | DYHLQtCCGSL | LKB1(STK11 | RegPhos |
| S505 | ERRCRsVELDL | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| T345 | GQASAtPFTDI | PhosphoSitePlus | |
| S405 | SNGVEsKSLTP | PhosphoSitePlus | |
| Y4 | __MKDyDELLK | PhosphoSitePlus | |
| Y269 | MQDYNyPVEWQ | PhosphoSitePlus | |
| Y163 | KGNKDyHLQTC | Pkinase | PhosphoSitePlus |
| Y97 | GELFDyIISQD | Pkinase | PhosphoSitePlus |
| S391 | ATPRTsQFTKY | PhosphoSitePlus | |
| T387 | STGAAtPRTSQ | PhosphoSitePlus | |
| Y438 | VKNEEyFMFPE | PhosphoSitePlus; HPRD | |
| T398 | FTKYWtESNGV | PhosphoSitePlus | |
| T459 | KREILtTPNRY | PhosphoSitePlus | |
| S171 | QTCCGsLAYAA | Pkinase | PhosphoSitePlus |
| T167 | DYHLQtCCGSL | LKB1 | phosphoELM |
| T489 | VNSTGtDKLMT | PhosphoSitePlus | |
| T466 | PNRYTtPSKAR | PhosphoSitePlus | |
| T428 | KENVYtPKSAV | PhosphoSitePlus | |
| S336 | RLRLSsFSCGQ | PhosphoSitePlus; HPRD; phosphoELM | |
| Y367 | ASDKNyVAGLI | PhosphoSitePlus | |
| Y267 | WIMQDyNYPVE | PhosphoSitePlus | |
| S529 | AKVFGsLERGL | PhosphoSitePlus; HPRD; SysPTM | |
| S356 | KSNNWsLEDVT | PhosphoSitePlus; HPRD; SysPTM | |
| T518 | AHMEEtPKRKG | PhosphoSitePlus; HPRD; SysPTM | |
| T409 | ESKSLtPALCR | PhosphoSitePlus | |
| T56 | LPRIKtEIEAL | Pkinase | PhosphoSitePlus |
| T478 | QCLKEtPIKIP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S338 | RLSSFsCGQAS | PhosphoSitePlus | |
| Dephosphorylation site |
| MELK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000298048 | T460M | Greenman2007, HPI | Ovarian Cancer | 17344846, 18428421 |
| Differential expressed protein |
| MELK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MELK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| STK11_HUMAN | MELK_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MELK_HUMAN | MPIP2_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | MELK_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| MELK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0061351 | neural precursor cell proliferation | IEA | biological_process |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0030097 | hemopoiesis | ISS | biological_process |
| GO:0004715 | non-membrane spanning protein tyrosine kinase acti | IDA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005509 | calcium ion binding | IDA | molecular_function |
| GO:0006915 | apoptotic process | IDA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005938 | cell cortex | IDA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0061351 | neural precursor cell proliferation | ISS | biological_process |
| GO:0043065 | positive regulation of apoptotic process | IEA | biological_process |
| GO:0008283 | cell proliferation | IDA | biological_process |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0009103 | lipopolysaccharide biosynthetic process | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0008289 | lipid binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0043065 | positive regulation of apoptotic process | ISS | biological_process |