Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MED1_HUMAN
Description:mediator complex subunit 1 [Source:HGNC Symbol;Acc:9234]
Location:chr17 q12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1431ASSKNyGSPLIPhosphoSitePlus
S179YLALQsLEQDLMed1PhosphoSitePlus
S1536ESWSKsPISSDPhosphoSitePlus
S151NFDEFsKHLKGMed1PhosphoSitePlus
S1401KHDGGsPSIKAPhosphoSitePlus; HPRD
S771MVRLSsSDSIGPhosphoSitePlus; HPRD; RegPhos
S784VTDILsDIAEEPhosphoSitePlus; phosphoELM; RegPhos
S1453PSHSKsPAYTPHPRD
S1147QSKNSsQSGGKPhosphoSitePlus
S446EVCPLsESRFSHPRD
S772VRLSSsDSIGPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1403DGGSPsIKAKVPhosphoSitePlus; HPRD
T1215KPVPGtPPSSKPhosphoSitePlus; HPRD; phosphoELM
T628TPPHHtPPPVSPhosphoSitePlus; HPRD
T805CPAIGtPLRDSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1192SKPNIsPSHSRPhosphoSitePlus; HPRD
S671LERQNsSSGSPPhosphoSitePlus
S1196ISPSHsRPPGGHPRD
S673RQNSSsGSPRMPhosphoSitePlus
Y224LMNLKyYVSPSMed1PhosphoSitePlus
S774LSSSDsIGPDVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1179PQGKPsSLMNPHPRD
T1032SNRPFtPPTSTPhosphoSitePlus; HPRD
S1481YQNSPsSDDGIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S887YFDESsQSGDNPhosphoSitePlus
T617GNGGStIGSSPHPRD
S1218PGTPPsSKAKSHPRD
S634PPPVSsMAGNTPhosphoSitePlus
S682RMEICsGSNKTPhosphoSitePlus
T1057PPGVAtPPIPKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1040TSTGGsKSPGSPhosphoSitePlus
S179YLALQsLEQDLHPRD
S1475SIAEKsYQNSPHPRD; phosphoELM
S1482QNSPSsDDGIRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T522TIQADtPALSLPhosphoSitePlus
S951LMEHHsGSQGPPhosphoSitePlus; HPRD
T1051AGRSQtPPGVAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S663STLYGsSPLERHPRD
S1134SSMYSsQGSSGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1437GSPLIsGSTPKPhosphoSitePlus
S1227KSPISsGSGGSPhosphoSitePlus; HPRD
S448CPLSEsRFSVSHPRD
S1021DTEGKsPSHSSPhosphoSitePlus
Y225MNLKYyVSPSDMed1PhosphoSitePlus
S588KDRHEsVGHGEPhosphoSitePlus; HPRD
S596HGEDFsKVSQNPhosphoSitePlus
S1156GKPGSsPITKHPhosphoSitePlus; HPRD
S1366DKSKVsTSGSSHPRD
S1251SSGLGsSGSLSPhosphoSitePlus
S675NSSSGsPRMEIPhosphoSitePlus
S1036FTPPTsTGGSKPhosphoSitePlus
T1457KSPAYtPQNLDErk2(MAPK1RegPhos
S620GSTIGsSPTPPPhosphoSitePlus
S770RMVRLsSSDSIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T623IGSSPtPPHHTHPRD
S1185SLMNPsLSKPNHPRD
S1081KPSSHsQYTSSPhosphoSitePlus
T1550SMTSNtILSADPhosphoSitePlus
S1252SGLGSsGSLSQPhosphoSitePlus; HPRD
S953EHHSGsQGPLLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S872PDLLNsQSQSGPhosphoSitePlus
S672ERQNSsSGSPRPhosphoSitePlus
S1045SKSPGsAGRSQPhosphoSitePlus
T1032SNRPFtPPTSTErk2(MAPK1RegPhos
S795ASKLPsTSDDCPhosphoSitePlus; phosphoELM; RegPhos
S1049GSAGRsQTPPGPhosphoSitePlus; HPRD
S1439PLISGsTPKHEPhosphoSitePlus; HPRD
T1387KNVGStGVAKIPhosphoSitePlus
S1433SKNYGsPLISGPhosphoSitePlus; HPRD
S1000RSRTPsNDGKSHPRD
S1187MNPSLsKPNISPhosphoSitePlus; HPRD
Y1476IAEKSyQNSPSHPRD
T1457KSPAYtPQNLDMAPK3phosphoELM
T780IGPDVtDILSDPhosphoSitePlus
T1032SNRPFtPPTSTErk1(MAPK3RegPhos
T1378DSSKKtSESKNPhosphoSitePlus
S1155GGKPGsSPITKPhosphoSitePlus; HPRD
S1207SDKLAsPMKPVPhosphoSitePlus; HPRD; phosphoELM
Y1132LSSSMySSQGSPhosphoSitePlus
S1238HMSGTsSSSGMHPRD
S1223SSKAKsPISSGPhosphoSitePlus; HPRD
T928NNQADtVDFSIPhosphoSitePlus
S1368SKVSTsGSSVDPhosphoSitePlus; HPRD
S1302RNKKPsLTAVIPhosphoSitePlus
S1465NLDSEsESGSSPhosphoSitePlus
S1226AKSPIsSGSGGHPRD
S1128SSSKLsSSMYSPhosphoSitePlus
S1042TGGSKsPGSAGPhosphoSitePlus
S874LLNSQsQSGFGPhosphoSitePlus
T1440LISGStPKHERPhosphoSitePlus; HPRD
S1479KSYQNsPSSDDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1141GSSGSsQSKNSPhosphoSitePlus
S1463PQNLDsESESGPhosphoSitePlus; HPRD; phosphoELM
S664TLYGSsPLERQPhosphoSitePlus; HPRD; phosphoELM
T1457KSPAYtPQNLDErk1(MAPK3RegPhos
S1133SSSMYsSQGSSPhosphoSitePlus
T796SKLPStSDDCPPhosphoSitePlus
S503VQRCMsIPVTMPhosphoSitePlus
S185LEQDLsKMAIMHPRD
T1457KSPAYtPQNLDMAPK1phosphoELM
S816SSSGHsQSTLFPhosphoSitePlus
T1159GSSPItKHGLSPhosphoSitePlus
S1548SLSMTsNTILSPhosphoSitePlus
T1457KSPAYtPQNLDPhosphoSitePlus
S18LSKMSsLLERLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T507MSIPVtMRAIRPhosphoSitePlus
Y1456SKSPAyTPQNLHPRD
S1347SKHNMsGGEFQPhosphoSitePlus; HPRD

Dephosphorylation site
MED1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000300651S1272FCOSMICSkin Cancer21984974
ENSP00000300651K792QCOSMICRenal Cancer20054297
ENSP00000300651H1526YCOSMICHead and Neck Cancer21798893
ENSP00000300651S673FCOSMICLung Cancer20668451
ENSP00000300651L841VCOSMICOvarian Cancer20668451
ENSP00000300651S1374FCOSMICHead and Neck Cancer21798893
ENSP00000300651P1157ACOSMICHead and Neck Cancer21798893
ENSP00000300651S1269FCOSMICHead and Neck Cancer21798893
ENSP00000300651G1580WCOSMICHead and Neck Cancer21798893
ENSP00000300651M1114ICOSMICSkin Cancer21984974
ENSP00000300651D521NCOSMICBreast Cancer20668451
ENSP00000300651R585QCOSMICPancreatic Cancer20668451
ENSP00000300651R1512SCOSMICHead and Neck Cancer21798893
ENSP00000300651T531ICOSMICHead and Neck Cancer21798893
ENSP00000300651G955SCOSMICOvarian Cancer21720365
ENSP00000300651G993ECOSMICMelanoma21499247
ENSP00000300651K1095ECOSMICSkin Cancer21984974
ENSP00000300651H815RCOSMICLung Cancer20668451

Differential expressed protein
MED1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MED1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANMED1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMED1_HUMANkinase -> substrateRegPhos
MK03_HUMANMED1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MED1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0030375thyroid hormone receptor coactivator activityIMPmolecular_function
GO:0035050embryonic heart tube developmentIEAbiological_process
GO:0006356regulation of transcription from RNA polymerase I IDAbiological_process
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0060744mammary gland branching involved in thelarcheIEAbiological_process
GO:0030216keratinocyte differentiationIMPbiological_process
GO:0001047core promoter bindingIDAmolecular_function
GO:0006260DNA replicationIEAbiological_process
GO:0048821erythrocyte developmentIEAbiological_process
GO:0048821erythrocyte developmentISSbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0042975peroxisome proliferator activated receptor bindingIPImolecular_function
GO:0048822enucleate erythrocyte developmentIEAbiological_process
GO:0002088lens development in camera-type eyeIEAbiological_process
GO:0006367transcription initiation from RNA polymerase II prIDAbiological_process
GO:0003712transcription cofactor activityIDAmolecular_function
GO:0071364cellular response to epidermal growth factor stimuIDAbiological_process
GO:0042789mRNA transcription from RNA polymerase II promoterIEAbiological_process
GO:0046966thyroid hormone receptor bindingIDAmolecular_function
GO:0003682chromatin bindingIMPmolecular_function
GO:0071383cellular response to steroid hormone stimulusIDAbiological_process
GO:0030331estrogen receptor bindingIPImolecular_function
GO:0004872receptor activityIDAmolecular_function
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function
GO:0060750epithelial cell proliferation involved in mammary IEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0035855megakaryocyte developmentISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0070318positive regulation of G0 to G1 transitionIEAbiological_process
GO:0030224monocyte differentiationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0035257nuclear hormone receptor bindingIEAmolecular_function
GO:0031100organ regenerationIEAbiological_process
GO:0043010camera-type eye developmentIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0033598mammary gland epithelial cell proliferationIEAbiological_process
GO:0006590thyroid hormone generationIEAbiological_process
GO:0045665negative regulation of neuron differentiationISSbiological_process
GO:0030518intracellular steroid hormone receptor signaling pIDAbiological_process
GO:0001525angiogenesisISSbiological_process
GO:0050693LBD domain bindingIPImolecular_function
GO:0016592mediator complexIEAcellular_component
GO:0002088lens development in camera-type eyeISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0045444fat cell differentiationIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0070371ERK1 and ERK2 cascadeIDAbiological_process
GO:0035162embryonic hemopoiesisIEAbiological_process
GO:0030521androgen receptor signaling pathwayIDAbiological_process
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0003222ventricular trabecula myocardium morphogenesisIEAbiological_process
GO:0035855megakaryocyte developmentIEAbiological_process
GO:2000347positive regulation of hepatocyte proliferationIEAbiological_process
GO:0036033mediator complex bindingIDAmolecular_function
GO:0060335positive regulation of interferon-gamma-mediated sIEAbiological_process
GO:0033601positive regulation of mammary gland epithelial ceIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0016922ligand-dependent nuclear receptor bindingIDAmolecular_function
GO:0000981sequence-specific DNA binding RNA polymerase II trISSmolecular_function
GO:0001889liver developmentIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:2001141regulation of RNA biosynthetic processIMPbiological_process
GO:0045618positive regulation of keratinocyte differentiatioIMPbiological_process
GO:0051726regulation of cell cycleNASbiological_process
GO:0030374ligand-dependent nuclear receptor transcription coNASmolecular_function
GO:0007595lactationIEAbiological_process
GO:0000902cell morphogenesisIMPbiological_process
GO:0033148positive regulation of intracellular estrogen receIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0010839negative regulation of keratinocyte proliferationIMPbiological_process
GO:0001892embryonic placenta developmentIEAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0002154thyroid hormone mediated signaling pathwayIMPbiological_process
GO:0001104RNA polymerase II transcription cofactor activityIDAmolecular_function
GO:0042789mRNA transcription from RNA polymerase II promoterISSbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0035116embryonic hindlimb morphogenesisIEAbiological_process
GO:0016592mediator complexIDAcellular_component
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0033160positive regulation of protein import into nucleusIEAbiological_process
GO:0097067cellular response to thyroid hormone stimulusIDAbiological_process
GO:0035729cellular response to hepatocyte growth factor stimIEAbiological_process
GO:0042809vitamin D receptor bindingNASmolecular_function
GO:0006702androgen biosynthetic processIMPbiological_process
GO:0042974retinoic acid receptor bindingIPImolecular_function
GO:0070562regulation of vitamin D receptor signaling pathwayIEAbiological_process
GO:0035357peroxisome proliferator activated receptor signaliIEAbiological_process
GO:0060745mammary gland branching involved in pregnancyIEAbiological_process
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:2000273positive regulation of receptor activityIMPbiological_process
GO:0003406retinal pigment epithelium developmentIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function